Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFJ8LT)

Drug Name
Ibutamoren Drug Info
Synonyms L 163191; MK-0667; MK-677; 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide
Cross-matching ID
PubChem CID
178024
ChEBI ID
CHEMBL13817
CAS Number
CAS 159634-47-6
TTD Drug ID
D02NEH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.93 1.27e-2 34/36 (94.44%) PCNA;POLE2;PRIM1;...
Cell cycle 1.87 2.55e-2 110/124 (88.71%) ORC1;ESPL1;CDC25B;...
Inflammatory mediator regulation of TRP channels -1.71 3.20e-2 82/98 (83.67%) GNAQ;PLCB2;ADCY7;...
Lysosome -1.73 2.39e-2 115/128 (89.84%) AP1M2;AP1S1;SCARB2;...
ABC transporters -1.73 2.66e-2 37/45 (82.22%) ABCA2;ABCA6;ABCA5;...
TNF signaling pathway -1.74 2.99e-2 103/112 (91.96%) SOCS3;ICAM1;AKT2;...
Vibrio cholerae infection -1.75 3.01e-2 44/50 (88%) ACTB;TJP1;PRKCA;...
Synaptic vesicle cycle -1.77 2.34e-2 63/78 (80.77%) ATP6V0A1;SLC6A1;STXBP1;...
T cell receptor signaling pathway -1.78 2.25e-2 93/104 (89.42%) AKT2;MAPK14;PAK1;...
Bile secretion -1.79 2.11e-2 68/90 (75.56%) PRKACA;EPHX1;HMGCR;...
Epithelial cell signaling in Helicobacter pylori infect... -1.83 1.88e-2 62/70 (88.57%) TJP1;MAPK14;PAK1;...
Primary bile acid biosynthesis -1.86 2.11e-2 15/17 (88.24%) SLC27A5;ACOT8;CYP7A1;...
IL-17 signaling pathway -1.93 0.00e+0 84/94 (89.36%) HSP90AA1;CCL2;CXCL1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H