Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFK9HG)

• Drug Name: Escitalopram Drug Info
• Synonyms: Esertia; Escitalopram [INN]; Cipralex (TN); Escitalopram (INN); Esertia (TN); Lexapro (TN); S(+)-Citalopram; (+)-(S)-1-(3-(Dimethylamino)propyl)-1-(p-fluorophenyl)-5-phthalancarbonitrile; (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile; (S)-Citalopram
• Therapeutic Class: Antidepressants
• Cross-matching ID:
  PubChem CID: 146570
  ChEBI ID: CHEMBL1508
  CAS Number: CAS 128196-01-0
  TTD Drug ID: D08RBC
  VARIDT Drug ID: DR00419
  INTEDE Drug ID: DR0618
  ACDINA Drug ID: D00242

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Systemic lupus erythematosus	2.10	0.00e+0	45/135 (33.33%)	HLA-DQA1;HLA-DPA1;HLA-DQB1;...
Th1 and Th2 cell differentiation	1.91	8.09e-3	80/92 (86.96%)	STAT1;LCK;HLA-DQA1;...
Viral protein interaction with cytokine and cytokine re...	1.86	5.40e-3	84/100 (84%)	CXCL9;CXCL10;CXCL11;...
Valine, leucine and isoleucine degradation	1.86	4.05e-3	42/48 (87.5%)	ALDH2;HMGCS1;ALDH3A2;...
Terpenoid backbone biosynthesis	1.82	4.86e-3	18/22 (81.82%)	HMGCS1;PDSS1;DHDDS;...
Tryptophan metabolism	1.78	1.08e-2	35/42 (83.33%)	CYP1B1;ALDH2;ALDH8A1;...
beta-Alanine metabolism	1.77	1.04e-2	25/30 (83.33%)	ALDH2;ALDH3A2;DPYD;...
Staphylococcus aureus infection	1.76	1.32e-2	72/95 (75.79%)	HLA-DQA1;HLA-DPA1;HLA-DQB1;...
Intestinal immune network for IgA production	1.73	2.34e-2	38/48 (79.17%)	HLA-DQA1;HLA-DPA1;HLA-DQB1;...
Lysine degradation	1.69	3.64e-2	51/63 (80.95%)	PLOD2;ALDH2;ALDH3A2;...
Oxidative phosphorylation	1.68	3.53e-2	93/133 (69.92%)	COX17;NDUFAB1;ATP5PF;...
Chemokine signaling pathway	1.66	4.05e-2	163/192 (84.9%)	CXCL9;CXCL10;STAT1;...
Platelet activation	1.63	4.86e-2	106/124 (85.48%)	RASGRP1;COL3A1;LCP2;...
Leishmaniasis	1.61	4.86e-2	67/77 (87.01%)	STAT1;HLA-DQA1;HLA-DPA1;...
Asthma	1.61	4.57e-2	25/31 (80.65%)	HLA-DQA1;HLA-DPA1;HLA-DQB1;...
Primary immunodeficiency	1.61	4.45e-2	33/38 (86.84%)	LCK;CD3D;CD8A;...
Sulfur metabolism	-1.80	4.17e-2	9/10 (90%)	MPST;SQOR;ETHE1;...
Mineral absorption	-1.97	1.19e-2	48/60 (80%)	HEPH;ATP2B4;ATP1B3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	10uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼