Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFKQ1W)

• Drug Name: T-98475 Drug Info
• Synonyms: T 98475; T-98475; UNII-F1KLT23O3A; 192887-28-8; F1KLT23O3A; CHEMBL71917; CHEMBL544440; 7-[(2,6-Difluorophenyl)methyl]-4,7-dihydro-2-[4-[(2-methyl-1-oxopropyl)amino]phenyl]-3-[[methyl(phenylmethyl)amino]methyl]-4-oxo-thieno[2,3-b]pyridine-5-carboxylic acid 1-methylethyl ester; 199119-18-1; GTPL1184; SCHEMBL7497514; CTK8E7257; CHEBI:93085; DTXSID90432134; MolPort-023-276-465; HMS3269M21; ZINC4424097; BDBM50067485; AKOS024457145; NCGC00167759-01; Isopropyl 3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobenzyl)-4,7-dihydro-2-(4-i
• Cross-matching ID:
  PubChem CID: 9874838
  ChEBI ID: CHEMBL71917
  CAS Number: CAS 192887-28-8
  TTD Drug ID: D02NCO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.53	0.00e+0	19/20 (95%)	MSMO1;DHCR24;SQLE;...
Terpenoid backbone biosynthesis	2.17	0.00e+0	18/22 (81.82%)	HMGCS1;IDI1;FDPS;...
Lysosome	2.17	0.00e+0	115/128 (89.84%)	CTSH;NEU1;NPC2;...
PPAR signaling pathway	2.06	0.00e+0	66/74 (89.19%)	HMGCS1;SCD;FADS2;...
Phagosome	1.93	8.04e-3	118/152 (77.63%)	TLR4;CYBB;CLEC7A;...
Biosynthesis of unsaturated fatty acids	1.88	1.51e-2	21/27 (77.78%)	SCD;FADS1;FADS2;...
Rheumatoid arthritis	1.84	2.44e-2	78/93 (83.87%)	TLR4;CTSK;VEGFA;...
Butanoate metabolism	1.78	3.77e-2	23/28 (82.14%)	HMGCS1;ACAT2;AACS;...
Fatty acid biosynthesis	1.75	4.80e-2	16/18 (88.89%)	ACSL1;FASN;ACSL3;...
Ascorbate and aldarate metabolism	1.75	4.52e-2	15/30 (50%)	UGDH;UGT2B28;ALDH2;...
Pentose and glucuronate interconversions	1.75	4.11e-2	17/34 (50%)	UGDH;UGT2B28;AKR1A1;...
Glycosaminoglycan degradation	1.74	4.02e-2	19/19 (100%)	GNS;HEXB;IDS;...
Synthesis and degradation of ketone bodies	1.71	4.48e-2	9/10 (90%)	HMGCS1;ACAT2;HMGCL
Tryptophan metabolism	1.71	4.16e-2	35/42 (83.33%)	ACAT2;CYP1B1;KYNU;...
Amino sugar and nucleotide sugar metabolism	1.70	3.95e-2	38/48 (79.17%)	GNPDA1;UGDH;HEXB;...
Viral protein interaction with cytokine and cytokine re...	1.69	4.77e-2	84/100 (84%)	CXCL5;TNFSF10;CX3CR1;...
Valine, leucine and isoleucine degradation	1.68	4.97e-2	42/48 (87.5%)	HMGCS1;ACAT2;AACS;...
Vibrio cholerae infection	1.67	4.69e-2	44/50 (88%)	ATP6AP1;SEC61G;ATP6V1C1;...
Cell cycle	-1.82	4.96e-3	110/124 (88.71%)	CDK2;CDC45;CCNB1;...
mRNA surveillance pathway	-1.86	4.25e-3	71/98 (72.45%)	FIP1L1;PPP2CA;GLE1;...
DNA replication	-1.89	1.65e-3	34/36 (94.44%)	DNA2;RFC5;RNASEH2A;...
Nitrogen metabolism	-1.90	1.98e-3	16/17 (94.12%)	CPS1;CA12;CA2
TGF-beta signaling pathway	-1.99	2.48e-3	81/94 (86.17%)	PPP2CA;TGFBR2;PPP2R1A;...
Spliceosome	-2.07	3.30e-3	101/150 (67.33%)	LSM7;SF3A2;CHERP;...
RNA transport	-2.19	4.96e-3	128/186 (68.82%)	NUP50;EIF2B3;POP5;...
Ribosome biogenesis in eukaryotes	-2.48	0.00e+0	52/108 (48.15%)	TBL3;IMP3;POP5;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼