Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFKV97)

Drug Name
AC1LG8KT Drug Info
Synonyms BAS 01816608; TCS JNK 5a
Cross-matching ID
PubChem CID
766949
ChEBI ID
CHEMBL233001
CAS Number
CAS 312917-14-9
TTD Drug ID
D0L0HG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycerolipid metabolism -1.60 4.28e-2 44/61 (72.13%) DGAT1;TKFC;DGKD;...
Collecting duct acid secretion -1.60 4.43e-2 22/27 (81.48%) TCIRG1;ATP4A;ATP6V1G1;...
Valine, leucine and isoleucine degradation -1.60 4.43e-2 42/48 (87.5%) ABAT;HIBCH;ACADM;...
Peroxisome -1.61 4.43e-2 72/82 (87.8%) ECH1;HMGCL;PEX1;...
Alanine, aspartate and glutamate metabolism -1.61 4.35e-2 27/37 (72.97%) GFPT2;ASRGL1;GLUL;...
Fatty acid degradation -1.61 4.52e-2 40/43 (93.02%) HADHB;GCDH;ECHS1;...
Retinol metabolism -1.61 4.57e-2 41/68 (60.29%) RETSAT;DHRS9;CYP26A1;...
Proximal tubule bicarbonate reclamation -1.62 4.34e-2 21/23 (91.3%) ATP1A3;ATP1B2;CA4;...
Glutathione metabolism -1.63 4.18e-2 43/57 (75.44%) PRDX6;GSTP1;GSR;...
One carbon pool by folate -1.64 4.17e-2 15/20 (75%) MTHFS;SHMT2;MTHFD2;...
Fructose and mannose metabolism -1.67 2.83e-2 30/33 (90.91%) HK2;SORD;FPGT;...
Allograft rejection -1.69 2.80e-2 32/38 (84.21%) HLA-DRB1;HLA-DQB1;HLA-E;...
Arachidonic acid metabolism -1.69 2.89e-2 48/61 (78.69%) CYP2J2;PLA2G12A;PLA2G6;...
Nitrogen metabolism -1.70 2.54e-2 16/17 (94.12%) CA8;CA9;CA4;...
Citrate cycle (TCA cycle) -1.73 1.52e-2 30/30 (100%) SUCLA2;ACLY;PC;...
Pyruvate metabolism -1.75 1.33e-2 41/47 (87.23%) ACACB;DLD;ADH1A;...
Mismatch repair -1.76 1.19e-2 22/23 (95.65%) POLD1;RPA1;MLH1;...
Pentose phosphate pathway -1.76 1.28e-2 25/30 (83.33%) TALDO1;FBP1;G6PD;...
Folate biosynthesis -1.77 1.39e-2 23/26 (88.46%) DHFR;MOCOS;AKR1B1;...
Glyoxylate and dicarboxylate metabolism -1.79 1.01e-2 23/30 (76.67%) MDH2;ACO2;DLD;...
Glycine, serine and threonine metabolism -1.79 1.11e-2 31/40 (77.5%) MAOA;DLD;SHMT2;...
Sulfur metabolism -1.85 7.39e-3 9/10 (90%) SELENBP1;TST;SUOX
Tryptophan metabolism -1.89 2.77e-3 35/42 (83.33%) MAOA;GCDH;ECHS1;...
Steroid hormone biosynthesis -1.90 1.58e-3 43/61 (70.49%) CYP21A2;CYP11B2;AKR1C4;...
beta-Alanine metabolism -1.93 0.00e+0 25/30 (83.33%) ABAT;HIBCH;ALDH9A1;...
Drug metabolism -2.07 0.00e+0 78/151 (51.66%) GSTM1;MAOA;FMO3;...
Pentose and glucuronate interconversions -2.11 0.00e+0 17/34 (50%) UGP2;DCXR;SORD;...
DNA replication -2.13 0.00e+0 34/36 (94.44%) MCM4;MCM5;RPA2;...
Glycolysis / Gluconeogenesis -2.18 0.00e+0 56/67 (83.58%) DLD;ADH1A;PKLR;...
Metabolism of xenobiotics by cytochrome P450 -2.36 0.00e+0 49/77 (63.64%) CBR1;HSD11B1;GSTK1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.04uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.04uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H