Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFLJHQ)

Drug Name
LCQ908 Drug Info
Synonyms
Pradigastat; LCQ-908; 956136-95-1; UNII-2U23G6VNUZ; LCQ908; 2U23G6VNUZ; LCQ 908; Pradigastat [USAN:INN]; LCQ 908NXA; 2-[4-[4-[5-[[6-(trifluoromethyl)pyridin-3-yl]amino]pyridin-2-yl]phenyl]cyclohexyl]acetic acid; 2-{4-[4-(5-{[6-(trifluoromethyl)pyridin-3-yl]amino}pyridin-2-yl)phenyl]cyclohexyl}acetic acid; Pradigastat (USAN); LCQ908-NXA; SCHEMBL180536; GTPL7830; SCHEMBL1289309; CHEMBL2364624; SCHEMBL18286769; SCHEMBL16104874; GXALXAKNHIROPE-UHFFFAOYSA-N; BCP21089; ZINC253387875; AKOS027338695; DB12866; SB16971; CS-1222
Cross-matching ID
PubChem CID
53387035
CAS Number
CAS 956136-95-1
TTD Drug ID
D0F1CE
INTEDE Drug ID
DR1877

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.17 0.00e+0 19/20 (95%) SQLE;DHCR24;SOAT1;...
Amoebiasis 2.08 7.21e-3 99/102 (97.06%) GNA15;COL4A5;LAMB1;...
Bladder cancer 1.79 4.33e-2 40/41 (97.56%) SRC;THBS1;E2F2;...
Viral protein interaction with cytokine and cytokine re... 1.78 4.57e-2 84/100 (84%) CXCL1;CCL20;CXCL2;...
Protein digestion and absorption 1.76 4.53e-2 78/103 (75.73%) COL4A5;COL4A6;CPB1;...
Gap junction 1.75 3.97e-2 72/88 (81.82%) SRC;GNAI1;GNAS;...
TNF signaling pathway 1.74 3.53e-2 103/112 (91.96%) TNFAIP3;CXCL1;CCL20;...
Cholesterol metabolism 1.71 4.69e-2 44/50 (88%) SOAT1;SORT1;CD36;...
Cytosolic DNA-sensing pathway 1.71 4.33e-2 52/63 (82.54%) CXCL10;IL1B;CCL4;...
Chagas disease 1.70 4.33e-2 93/102 (91.18%) GNA15;GNAI1;GNAS;...
C-type lectin receptor signaling pathway 1.70 4.23e-2 93/104 (89.42%) SRC;IL1B;MAPK13;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H