Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFLOT4)

Drug Name
SDZ-WAG-994 Drug Info
Synonyms WAG-994
Cross-matching ID
PubChem CID
164305
CAS Number
CAS 130714-47-5
TTD Drug ID
D08ZBT

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
RNA polymerase 2.03 0.00e+0 23/31 (74.19%) POLR2I;POLR1C;POLR2F;...
Proteasome 1.89 9.25e-3 44/46 (95.65%) PSMB9;PSMC6;PSMA3;...
Malaria 1.85 2.16e-2 44/50 (88%) TLR4;COMP;THBS2;...
Legionellosis 1.82 2.31e-2 51/57 (89.47%) HSPA8;TLR4;ITGAM;...
Rheumatoid arthritis 1.79 2.77e-2 78/93 (83.87%) ANGPT1;MMP3;CTSK;...
Ribosome biogenesis in eukaryotes 1.79 2.62e-2 52/108 (48.15%) REXO2;RRP7A;XPO1;...
Protein digestion and absorption 1.78 2.64e-2 78/103 (75.73%) COL5A1;COL6A2;COL3A1;...
Graft-versus-host disease 1.77 2.43e-2 32/42 (76.19%) GZMB;HLA-DQB1;HLA-DRA;...
Spliceosome 1.73 3.29e-2 101/150 (67.33%) HSPA8;PPIH;SRSF7;...
Asthma 1.69 4.53e-2 25/31 (80.65%) HLA-DQB1;HLA-DRA;RNASE3;...
Intestinal immune network for IgA production 1.67 4.79e-2 38/48 (79.17%) HLA-DQB1;HLA-DRA;TNFSF13;...
Inflammatory bowel disease 1.67 4.47e-2 58/65 (89.23%) TLR4;STAT3;TGFB2;...
Cortisol synthesis and secretion -1.76 4.95e-2 58/65 (89.23%) PLCB3;KCNK3;CACNA1D;...
Glycerolipid metabolism -1.81 3.76e-2 44/61 (72.13%) PNLIPRP2;GK;LIPF;...
Other glycan degradation -1.90 1.08e-2 13/18 (72.22%) MAN2B1;FUCA1;NEU1;...
Tyrosine metabolism -1.96 5.38e-3 30/36 (83.33%) ADH6;ADH1A;ADH7;...
Mineral absorption -2.10 0.00e+0 48/60 (80%) STEAP1;ATP1A2;TF;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H