Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFMDOB)

• Drug Name: Carteolol Drug Info
• Synonyms: Carteololum; Carteolol HCl; Carteolol Monohydrochloride; Arteolol (TN); Arteoptic (TN); Calte (TN); Carteol (TN); Carteolol (INN); Carteolol [INN:BAN]; Carteololum [INN-Latin]; Cartrol (TN); Elebloc (TN); Endak (TN); Glauteolol (TN); Mikelan (TN); Ocupress (TN); Poenglaucol (TN); Singlauc (TN); Teoptic (TN); 5-({3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl}oxy)-3,4-dihydroquinolin-2(1H)-one; 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one; 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydroquinolin-2(1H)-one
• Therapeutic Class: Antihypertensive Agents
• Cross-matching ID:
  PubChem CID: 2583
  ChEBI ID: CHEMBL839
  CAS Number: CAS 51781-06-7
  TTD Drug ID: D03GCJ
  INTEDE Drug ID: DR0281

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Staphylococcus aureus infection	2.08	0.00e+0	72/95 (75.79%)	DEFB1;CFB;KRT14;...
Proteasome	1.98	4.67e-3	44/46 (95.65%)	PSMB3;PSMA5;PSMB4;...
Folate biosynthesis	1.97	3.12e-3	23/26 (88.46%)	AKR1C3;PAH;FPGS;...
Complement and coagulation cascades	1.87	1.64e-2	76/85 (89.41%)	CD59;CFB;F12;...
DNA replication	1.81	2.06e-2	34/36 (94.44%)	DNA2;FEN1;PRIM2;...
Oxidative phosphorylation	1.76	2.65e-2	93/133 (69.92%)	ATP5MG;NDUFA8;ATP5MC1;...
Pantothenate and CoA biosynthesis	1.75	2.54e-2	14/21 (66.67%)	AASDHPPT;DPYD;PANK3;...
Metabolism of xenobiotics by cytochrome P450	1.69	4.44e-2	49/77 (63.64%)	AKR7A2;UGT2B17;UGT2B15;...
N-Glycan biosynthesis	1.68	4.57e-2	38/50 (76%)	ALG8;ST6GAL1;DPAGT1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	6.66uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼