Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFN07X)

Drug Name
Nilutamide Drug Info
Synonyms
Anandron; Nilandron; Nilandrone; Nilutamida; Nilutamidum; Aventis Behring Brand of Nilutamide; Aventis Brand of Nilutamide; Hoechst Brand of Nilutamide; Nilutamida [Spanish]; Nilutamidum [Latin]; N 8534; RU 23908; Anandron (TN); RU 23908-10; RU-23908; Nilutamide (USAN/INN); Nilutamide [USAN:BAN:INN]; Nilutamide [USAN:INN:BAN]; 1-(3'-Trifluoromethyl-4'-nitrophenyl)-4,4-dimethylimidazolidine-2,5-dione; 5,5-Dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)-2,4-imidazolidinedione; 5,5-Dimethyl-3-(alpha,alpha,alpha-trifluoro-4-nitro-m-tolyl)hydantoin; 5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione; 5,5-dimethyl-3-(4-nitro-3-(trifluoromethyl)phenyl)-2,4-imidazolidinedione; 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
4493
ChEBI ID
CHEMBL1274
CAS Number
CAS 63612-50-0
TTD Drug ID
D0SN9T
INTEDE Drug ID
DR1158
ACDINA Drug ID
D00469

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Aminoacyl-tRNA biosynthesis 2.10 0.00e+0 15/66 (22.73%) WARS2;QRSL1;IARS2;...
One carbon pool by folate 1.82 3.80e-2 15/20 (75%) MTHFD1;ATIC;GART;...
Serotonergic synapse -1.71 3.60e-2 97/114 (85.09%) PLA2G4C;HTR2A;KCNJ3;...
Chagas disease -1.71 3.56e-2 93/102 (91.18%) MYD88;IFNGR2;JUN;...
Natural killer cell mediated cytotoxicity -1.71 3.77e-2 99/131 (75.57%) FYN;IFNA21;KIR2DL1;...
Pertussis -1.72 3.72e-2 64/76 (84.21%) SERPING1;C1S;NOD1;...
Bile secretion -1.72 3.97e-2 68/90 (75.56%) ADCY7;ATP1B2;RXRA;...
Long-term depression -1.77 2.45e-2 55/60 (91.67%) PRKCA;GRIA1;CACNA1A;...
Phagosome -1.78 2.52e-2 118/152 (77.63%) CANX;FCGR2A;COMP;...
Neutrophil extracellular trap formation -1.79 2.60e-2 101/189 (53.44%) PRKCA;ATG7;CLEC7A;...
Protein processing in endoplasmic reticulum -1.83 2.03e-2 127/171 (74.27%) EDEM3;LMAN2;HSPA1L;...
Legionellosis -1.85 1.49e-2 51/57 (89.47%) TLR5;MYD88;ARF1;...
Staphylococcus aureus infection -1.86 1.65e-2 72/95 (75.79%) FPR2;KRT10;FCGR2C;...
IL-17 signaling pathway -1.87 1.67e-2 84/94 (89.36%) IL5;MMP13;JUN;...
Gastric acid secretion -1.88 1.49e-2 63/76 (82.89%) CHRM3;PRKCA;CAMK2A;...
Malaria -1.91 1.49e-2 44/50 (88%) CD81;LRP1;MYD88;...
Amoebiasis -1.91 1.79e-2 99/102 (97.06%) PIK3R1;PRKACB;LAMC1;...
Morphine addiction -1.93 2.23e-2 80/91 (87.91%) KCNJ3;PRKACB;GNB2;...
Glutamatergic synapse -1.99 9.92e-3 97/114 (85.09%) GRM6;SLC1A2;GRM2;...
Nicotine addiction -1.99 1.49e-2 32/40 (80%) GRIA3;GRIN2B;GABRB2;...
GABAergic synapse -2.05 2.98e-2 76/89 (85.39%) PRKACB;GNB2;CACNA1D;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
SK-N-SH CVCL_0531 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H