Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFO843)

Drug Name
Fluspirilene Drug Info
Synonyms
Fluspirilen; Fluspirileno; Fluspirilenum; Imap; Redeptin; Spirodiflamine; R 6218; F-100; Fluspirileno [INN-Spanish]; Fluspirilenum [INN-Latin]; Imap (TN); Spiropiperidine analogue, 1; Fluspirilene (USAN/INN); Fluspirilene [USAN:INN:BAN]; McN-JR-6218; 1-Phenyl-4-oxo-8-(4,4-bis(4-fluorophenyl)butyl)-1,3,8-triazaspiro(4,5)decane; 8-(4,4-Bis(p-fluorophenyl)butyl)-1-phenyl-1,3,8-triazaspiro-(4.5)decan-4-one; 8-[4,4-bis (p-fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4,5]decan-4-one; 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one; 8-[4,4-bis(4-fluorophenyl)butyl]-4-phenyl-2,4,8-triazaspiro[4.5]decan-1-one; 8-[4,4-bis(p-Fluorophenyl)butyl]-1-phenyl-1,3,8-triazino[4.5]decan-4-one
Therapeutic ClassAntipsychotic Agents
Cross-matching ID
PubChem CID
3396
ChEBI ID
CHEMBL46516
CAS Number
CAS 1841-19-6
TTD Drug ID
D0U5FS
INTEDE Drug ID
DR0732

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Terpenoid backbone biosynthesis 2.46 0.00e+0 18/22 (81.82%) HMGCS1;IDI1;ACAT2;...
Steroid biosynthesis 2.45 0.00e+0 19/20 (95%) MSMO1;SQLE;CYP51A1;...
PPAR signaling pathway 2.25 0.00e+0 66/74 (89.19%) HMGCS1;SCD;DBI;...
Retinol metabolism 2.08 2.35e-3 41/68 (60.29%) UGT2B28;RDH11;CYP2C9;...
Biosynthesis of unsaturated fatty acids 2.07 1.88e-3 21/27 (77.78%) SCD;FADS1;FADS2;...
Steroid hormone biosynthesis 2.06 1.57e-3 43/61 (70.49%) HSD17B7;UGT2B28;CYP1B1;...
Cholesterol metabolism 1.92 1.08e-2 44/50 (88%) LDLR;APOA1;LIPG;...
Butanoate metabolism 1.90 1.29e-2 23/28 (82.14%) HMGCS1;ACAT2;AACS;...
Synthesis and degradation of ketone bodies 1.87 1.15e-2 9/10 (90%) HMGCS1;ACAT2;HMGCS2
Primary bile acid biosynthesis 1.84 1.69e-2 15/17 (88.24%) ACOX2;CYP27A1;SCP2;...
Metabolism of xenobiotics by cytochrome P450 1.83 1.88e-2 49/77 (63.64%) UGT2B28;GSTA1;CYP1B1;...
Drug metabolism 1.82 1.80e-2 78/151 (51.66%) UGT2B28;GSTA1;DPYS;...
Pentose and glucuronate interconversions 1.78 2.32e-2 17/34 (50%) UGT2B28;UGT2B4;AKR1B10;...
Peroxisome 1.75 3.29e-2 72/82 (87.8%) ACSL3;IDH1;PIPOX;...
Vibrio cholerae infection 1.71 4.71e-2 44/50 (88%) ATP6V1A;PRKCA;ATP6V1D;...
Ascorbate and aldarate metabolism 1.68 4.98e-2 15/30 (50%) UGT2B28;UGT2B4;UGT2B15;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 4uM 6H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 4uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 4uM 6H
MDST8 CVCL_1400 Homo sapiens 4uM 6H
NCI-H508 CVCL_1561 Homo sapiens 4uM 6H
SNU-1040 CVCL_5001 Homo sapiens 4uM 6H
SNU-C4 CVCL_5008 Homo sapiens 4uM 6H
SNU-C5 CVCL_5009 Homo sapiens 4uM 6H
SW480 CVCL_0546 Homo sapiens 4uM 6H
SW620 CVCL_0547 Homo sapiens 4uM 6H
SW948 CVCL_0550 Homo sapiens 4uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 4uM 6H
HT115 CVCL_1294 Homo sapiens 4uM 6H
RKO CVCL_0504 Homo sapiens 4uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 4uM 6H
SNG-M CVCL_1707 Homo sapiens 4uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 4uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 4uM - 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 6.66uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 4uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 4uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 4uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 4uM 6H
T3M-10 CVCL_1729 Homo sapiens 4uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 4uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 4uM 6H
HCC515 CVCL_5134 Homo sapiens 4uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 4uM 6H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 4uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 4uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 4uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 4uM 6H
OV7 CVCL_1623 Homo sapiens 4uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 4uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 4uM 6H
RMUG-S CVCL_1666 Homo sapiens 4uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 4uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 4uM 6H
PL-21 CVCL_2161 Homo sapiens 4uM 6H
SKM-1 CVCL_0010 Homo sapiens 4uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 4uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 4uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 4uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 4uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 4uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H