Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFOTZ7)

Drug Name
Racecadotril Drug Info
Synonyms Acetorphan; Hidrasec; Tiorfan
Cross-matching ID
PubChem CID
107751
ChEBI ID
CHEMBL2103772
CAS Number
CAS 81110-73-8
TTD Drug ID
D0JY3V

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Spliceosome 2.12 0.00e+0 101/150 (67.33%) SRSF5;HSPA8;PRPF8;...
RNA transport 1.92 1.55e-2 128/186 (68.82%) EIF4G1;PNN;RANBP2;...
Asthma -1.63 3.71e-2 25/31 (80.65%) HLA-DOB;FCER1G;EPX;...
Hematopoietic cell lineage -1.63 3.68e-2 90/99 (90.91%) TNF;CD5;GP1BA;...
Fat digestion and absorption -1.64 3.49e-2 35/43 (81.4%) PLA2G2A;DGAT1;MTTP;...
Porphyrin and chlorophyll metabolism -1.65 3.45e-2 23/43 (53.49%) ALAS1;FECH;FXN;...
VEGF signaling pathway -1.65 3.36e-2 50/59 (84.75%) MAPK1;CASP9;MAPK3;...
Steroid hormone biosynthesis -1.66 3.40e-2 43/61 (70.49%) DHRS11;CYP3A4;HSD17B7;...
Peroxisome -1.66 3.50e-2 72/82 (87.8%) PEX10;PEX14;ACOX3;...
Leishmaniasis -1.67 2.66e-2 67/77 (87.01%) PTGS2;TNF;NFKBIB;...
Toll-like receptor signaling pathway -1.70 2.32e-2 94/104 (90.38%) RELA;MAPK1;SPP1;...
Osteoclast differentiation -1.71 2.22e-2 117/127 (92.13%) RELA;MAPK1;SOCS3;...
Th17 cell differentiation -1.72 2.21e-2 95/107 (88.79%) NFKBIB;IFNGR2;RELA;...
Viral protein interaction with cytokine and cytokine re... -1.75 1.61e-2 84/100 (84%) CCL22;CXCR5;CXCL12;...
T cell receptor signaling pathway -1.77 1.45e-2 93/104 (89.42%) RELA;CD247;MAPK1;...
Primary immunodeficiency -1.77 1.54e-2 33/38 (86.84%) IKBKG;CD8B;IL2RG;...
Arginine biosynthesis -1.77 1.63e-2 17/22 (77.27%) ARG2;CPS1;GOT1;...
Inflammatory bowel disease -1.77 1.74e-2 58/65 (89.23%) IFNGR2;RELA;IL18R1;...
NF-kappa B signaling pathway -1.78 1.54e-2 90/104 (86.54%) DDX58;BIRC2;CFLAR;...
Glycine, serine and threonine metabolism -1.80 1.40e-2 31/40 (77.5%) SHMT2;ALAS2;BHMT;...
Influenza A -1.83 1.23e-2 156/172 (90.7%) PIK3CB;CALCOCO2;ICAM1;...
PD-L1 expression and PD-1 checkpoint pathway in cancer -1.83 1.24e-2 79/89 (88.76%) NFKBIB;EGF;IFNGR2;...
Allograft rejection -1.84 1.36e-2 32/38 (84.21%) HLA-DOA;IL10;HLA-DPA1;...
Type I diabetes mellitus -1.84 1.39e-2 38/43 (88.37%) HLA-DRB1;FAS;ICA1;...
Graft-versus-host disease -1.84 1.56e-2 32/42 (76.19%) KLRD1;HLA-DRB1;FAS;...
Glutathione metabolism -1.87 1.13e-2 43/57 (75.44%) GSS;MGST2;PRDX6;...
Metabolism of xenobiotics by cytochrome P450 -1.88 7.56e-3 49/77 (63.64%) CYP2F1;HSD11B1;CYP2C9;...
Rheumatoid arthritis -1.93 6.81e-3 78/93 (83.87%) TNFRSF11A;ATP6V0A2;HLA-DOA;...
Ferroptosis -1.94 8.51e-3 36/41 (87.8%) LPCAT3;FTL;GSS;...
Staphylococcus aureus infection -1.97 3.78e-3 72/95 (75.79%) IL10;HLA-DPA1;DEFA6;...
Alanine, aspartate and glutamate metabolism -2.00 0.00e+0 27/37 (72.97%) ADSL;ABAT;GFPT2;...
Mineral absorption -2.20 0.00e+0 48/60 (80%) SLC31A1;ATP2B1;STEAP1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 4uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 8uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H