Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFPOUC)

Drug Name
CGP-57380 Drug Info
Synonyms
CGP 57380; 522629-08-9; CGP-57380; MNK1 Inhibitor; N3-(4-fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamine; CGP57380; CHEMBL1240885; C11H9FN6; 4-Amino-5-(4-fluoroanilino)-pyrazolo[3,4-d]pyrimidine; SCHEMBL987991; GTPL6010; CHEMBL576817; SCHEMBL16714452; CHEBI:92749; DTXSID50469941; MolPort-006-725-822; HMS3653G22; HMS3269P13; HMS3263L14; HMS3229K20; HMS3648M14; Tox21_501256; BDBM50130693; 2314AH; NSC741567; MFCD03861062; ZINC13816313; s7421; IN1236; BDBM50298223; AKOS024457265; CCG-206868; NSC-741567; LP01256; NCGC00162380-06
Cross-matching ID
PubChem CID
11644425
ChEBI ID
CHEMBL1240885
CAS Number
CAS 522629-08-9
TTD Drug ID
D0A7FQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Alanine, aspartate and glutamate metabolism 2.18 0.00e+0 27/37 (72.97%) ASNS;ASS1;GOT1;...
Arginine biosynthesis 2.02 0.00e+0 17/22 (77.27%) ASS1;GOT1;ASL;...
Cysteine and methionine metabolism 1.99 0.00e+0 43/50 (86%) PSAT1;PHGDH;CBS;...
Glycine, serine and threonine metabolism 1.97 2.42e-3 31/40 (77.5%) PSAT1;PHGDH;CBS;...
Selenocompound metabolism 1.85 2.13e-2 11/17 (64.71%) CTH;TXNRD1;PAPSS2;...
Dilated cardiomyopathy 1.83 2.10e-2 86/96 (89.58%) TTN;ATP2A2;MYL2;...
Histidine metabolism 1.83 1.94e-2 16/22 (72.73%) HNMT;ALDH2;ALDH3A2;...
One carbon pool by folate 1.77 4.11e-2 15/20 (75%) SHMT2;MTHFD2
Antigen processing and presentation -1.66 4.75e-2 60/78 (76.92%) HSPA4;HLA-DRB1;HLA-DPA1;...
DNA replication -1.67 4.47e-2 34/36 (94.44%) RNASEH1;POLA1;DNA2;...
Rheumatoid arthritis -1.68 4.33e-2 78/93 (83.87%) CCL5;CCL20;IL18;...
Ribosome biogenesis in eukaryotes -1.75 1.70e-2 52/108 (48.15%) RBM28;POP7;REXO5;...
ECM-receptor interaction -1.76 1.56e-2 80/88 (90.91%) THBS4;CD44;ITGA1;...
Mismatch repair -1.77 1.62e-2 22/23 (95.65%) POLD4;RFC5;RFC3;...
Proteasome -1.77 1.69e-2 44/46 (95.65%) PSMC3;PSMF1;POMP;...
Base excision repair -1.80 1.63e-2 29/33 (87.88%) POLE2;POLD4;POLD1;...
Biosynthesis of unsaturated fatty acids -1.83 8.66e-3 21/27 (77.78%) BAAT;HSD17B4;ACAA1;...
Terpenoid backbone biosynthesis -1.86 6.23e-3 18/22 (81.82%) PDSS1;DHDDS;ACAT2;...
Aldosterone-regulated sodium reabsorption -1.88 5.19e-3 34/37 (91.89%) PRKCA;INS;PIK3R1;...
IL-17 signaling pathway -1.98 0.00e+0 84/94 (89.36%) TRAF3IP2;CXCL3;IL1B;...
Spliceosome -2.16 0.00e+0 101/150 (67.33%) CDC5L;SRSF1;SF3A3;...
Steroid biosynthesis -2.27 0.00e+0 19/20 (95%) FDFT1;HSD17B7;CYP51A1;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.37uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H