Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFSAK3)

Drug Name
IAA-94 Drug Info
Synonyms indanyloxyacetic acid 94; MK-473
Cross-matching ID
PubChem CID
3667
CAS Number
CAS 53108-00-2
TTD Drug ID
D02MYV

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Propanoate metabolism 1.98 0.00e+0 30/34 (88.24%) PCCB;ACAT1;ABAT;...
DNA replication 1.90 2.02e-2 34/36 (94.44%) RFC2;PCNA;MCM5;...
Butanoate metabolism 1.86 2.69e-2 23/28 (82.14%) ACAT1;ABAT;BDH2;...
Arginine biosynthesis 1.73 4.63e-2 17/22 (77.27%) CPS1;ASL;GLS;...
Synthesis and degradation of ketone bodies 1.72 4.53e-2 9/10 (90%) ACAT1;BDH2;ACAT2;...
Drug metabolism 1.70 4.32e-2 78/151 (51.66%) UGT2B28;HPRT1;GUSB;...
Base excision repair 1.70 4.03e-2 29/33 (87.88%) PCNA;OGG1;FEN1;...
Systemic lupus erythematosus 1.69 3.69e-2 45/135 (33.33%) HLA-DPB1;C1QA;HLA-DQA1;...
Fructose and mannose metabolism 1.68 3.83e-2 30/33 (90.91%) PFKM;HK2;AKR1B10;...
Non-alcoholic fatty liver disease -1.73 4.26e-2 126/155 (81.29%) MAPK14;NDUFV2;IL1B;...
Circadian rhythm -1.74 3.97e-2 26/31 (83.87%) CLOCK;PRKAB2;BHLHE40;...
Kaposi sarcoma-associated herpesvirus infection -1.77 3.38e-2 172/193 (89.12%) CSF2;PPP3CB;PIK3R1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.80 2.98e-2 62/70 (88.57%) MAPK9;ATP6V0A4;RELA;...
Mineral absorption -1.82 1.99e-2 48/60 (80%) ATP2B4;STEAP1;TF;...
Legionellosis -2.02 4.97e-3 51/57 (89.47%) EEF1A2;VCP;BCL2L13;...
TNF signaling pathway -2.03 9.94e-3 103/112 (91.96%) CSF2;PIK3R1;PTGS2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 3.33uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 3.33uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 3.33uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 3.33uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 3.33uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 3.33uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 3.33uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 3.33uM - 10uM 24H