Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFWMKZ)

Drug Name
ZK-93423 Drug Info
Synonyms
ZK 93423; 83910-44-5; ZK93423; ZK 93 423; 6-Benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylic acid ethyl ester; 9H-Pyrido(3,4-b)indole-3-carboxylic acid, 4-(methoxymethyl)-6-(phenylmethoxy)-, ethyl ester; ALBKMJDFBZVHAK-UHFFFAOYSA-N; PDSP1_001754; AC1L3TNV; AC1Q64YI; CHEMBL10947; GTPL4346; SCHEMBL7117282; CHEMBL1518572; BDBM85039; CHEBI:92593; ZINC5857871; PDSP2_001737; PDSP1_001771; ethyl 6-(benzyloxy)-4-(methoxymethyl)-9h-; BDBM50007553; PDSP2_001754; CAS_121926; NSC_121926
Cross-matching ID
PubChem CID
121926
ChEBI ID
CHEMBL1518572
CAS Number
CAS 83910-44-5
TTD Drug ID
D07ZCK

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Glycine, serine and threonine metabolism 1.98 2.41e-2 31/40 (77.5%) CBS;PHGDH;DLD;...
Cysteine and methionine metabolism 1.92 1.21e-2 43/50 (86%) CBS;ENOPH1;PHGDH;...
Renin-angiotensin system 1.87 8.04e-3 20/23 (86.96%) ANPEP;AGT;ACE2;...
Bladder cancer 1.83 2.41e-2 40/41 (97.56%) VEGFA;CXCL8;FGFR3;...
Arginine and proline metabolism 1.82 2.17e-2 39/50 (78%) CKB;AOC1;ALDH3A2;...
Long-term potentiation 1.80 2.61e-2 61/67 (91.04%) RPS6KA2;PPP3CA;ATF4;...
Glycolysis / Gluconeogenesis 1.76 3.62e-2 56/67 (83.58%) PCK2;PFKP;DLD;...
Tryptophan metabolism 1.76 3.32e-2 35/42 (83.33%) DLD;AOC1;KYAT3;...
Phospholipase D signaling pathway 1.75 3.22e-2 134/148 (90.54%) CXCL8;PDGFA;PDGFRA;...
Central carbon metabolism in cancer 1.74 3.02e-2 67/70 (95.71%) PFKP;PDGFRA;SLC7A5;...
Endometrial cancer 1.74 2.74e-2 56/58 (96.55%) CDKN1A;PIK3CB;CTNNB1;...
Selenocompound metabolism 1.74 2.71e-2 11/17 (64.71%) KYAT3;CTH;SEPHS1;...
NF-kappa B signaling pathway 1.71 3.53e-2 90/104 (86.54%) CXCL2;CXCL3;CXCL8;...
Proximal tubule bicarbonate reclamation 1.71 3.36e-2 21/23 (91.3%) PCK2;FXYD2;CA2;...
Cardiac muscle contraction 1.71 3.22e-2 64/87 (73.56%) FXYD2;COX7A1;MYL2;...
Pentose phosphate pathway 1.71 3.02e-2 25/30 (83.33%) PFKP;ALDOB;PFKM;...
ErbB signaling pathway 1.70 3.41e-2 79/85 (92.94%) AREG;EREG;EIF4EBP1;...
Alanine, aspartate and glutamate metabolism 1.69 3.28e-2 27/37 (72.97%) ASNS;GLUD1;GFPT1;...
Gap junction 1.69 3.18e-2 72/88 (81.82%) PDGFA;PDGFRA;ITPR3;...
Citrate cycle (TCA cycle) 1.68 3.08e-2 30/30 (100%) PCK2;DLD;PCK1;...
Amino sugar and nucleotide sugar metabolism 1.64 4.94e-2 38/48 (79.17%) GMDS;HK2;CMAS;...
VEGF signaling pathway 1.64 4.83e-2 50/59 (84.75%) VEGFA;PPP3CA;PIK3CB;...
Complement and coagulation cascades -1.59 4.78e-2 76/85 (89.41%) C2;SERPIND1;C7;...
Epstein-Barr virus infection -1.60 4.41e-2 189/202 (93.56%) MAP2K6;JAK1;PSMD4;...
Type I diabetes mellitus -1.62 4.17e-2 38/43 (88.37%) CD86;TNF;GAD1;...
Graft-versus-host disease -1.63 4.11e-2 32/42 (76.19%) HLA-DPB1;IFNG;HLA-DRA;...
Phagosome -1.67 3.04e-2 118/152 (77.63%) MBL2;STX12;MSR1;...
Mismatch repair -1.68 3.12e-2 22/23 (95.65%) RFC2;RFC3;POLD3;...
Herpes simplex virus 1 infection -1.70 3.01e-2 165/498 (33.13%) STAT2;TNF;TBK1;...
Protein processing in endoplasmic reticulum -1.73 2.59e-2 127/171 (74.27%) HSP90B1;SEC61A1;YOD1;...
Asthma -1.77 2.00e-2 25/31 (80.65%) TNF;RNASE3;HLA-DPB1;...
Allograft rejection -1.86 8.99e-3 32/38 (84.21%) HLA-DPB1;IFNG;HLA-DRA;...
mRNA surveillance pathway -1.86 9.25e-3 71/98 (72.45%) PPP2R1B;NXF3;EIF4A3;...
Staphylococcus aureus infection -1.88 9.59e-3 72/95 (75.79%) C2;PTAFR;KRT24;...
Autoimmune thyroid disease -1.92 4.32e-3 46/53 (86.79%) TSHB;TG;CD86;...
Systemic lupus erythematosus -2.11 0.00e+0 45/135 (33.33%) C2;C7;C8B;...
DNA replication -2.15 0.00e+0 34/36 (94.44%) MCM2;POLE2;MCM4;...
Antigen processing and presentation -2.26 0.00e+0 60/78 (76.92%) CTSB;PSME3;CREB1;...
Spliceosome -2.36 0.00e+0 101/150 (67.33%) SNRPA1;SNRPB2;DHX15;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 2.5uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 2.5uM - 10uM 6H, 24H
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 3.33uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H