Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFXUT8)

Drug Name
Oxymetholone Drug Info
Synonyms oxymetholone; Anasterone; 434-07-1; HMS3393H15
Cross-matching ID
PubChem CID
5281034
ChEBI ID
CHEMBL7864
CAS Number
CAS 434-07-1
TTD Drug ID
D0Q6NZ
INTEDE Drug ID
DR1225

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
IL-17 signaling pathway 2.15 0.00e+0 84/94 (89.36%) CXCL1;S100A8;S100A9;...
Glutathione metabolism 2.08 0.00e+0 43/57 (75.44%) GCLM;G6PD;GPX3;...
Folate biosynthesis 2.00 3.00e-3 23/26 (88.46%) AKR1B10;AKR1C3;AKR1B1;...
Steroid hormone biosynthesis 1.99 4.50e-3 43/61 (70.49%) AKR1C2;AKR1C1;AKR1C3;...
Pertussis 1.93 3.60e-3 64/76 (84.21%) CXCL6;CXCL8;C1S;...
Metabolism of xenobiotics by cytochrome P450 1.89 6.00e-3 49/77 (63.64%) AKR1C1;ALDH3A1;ADH1B;...
Protein processing in endoplasmic reticulum 1.86 9.01e-3 127/171 (74.27%) HSPA1A;CKAP4;DDIT3;...
Legionellosis 1.84 7.88e-3 51/57 (89.47%) CXCL1;HSPA1A;CXCL8;...
Glycerolipid metabolism 1.83 8.01e-3 44/61 (72.13%) AKR1B10;AKR1B1;GLA;...
Pentose and glucuronate interconversions 1.79 1.71e-2 17/34 (50%) AKR1B10;UGDH;AKR1B1;...
Fluid shear stress and atherosclerosis 1.72 3.36e-2 123/139 (88.49%) HMOX1;SQSTM1;NQO1;...
alpha-Linolenic acid metabolism -1.69 3.93e-2 17/25 (68%) PLA2G5;PLA2G6;ACAA1;...
Valine, leucine and isoleucine degradation -1.73 2.75e-2 42/48 (87.5%) ACAA1;BCKDHB;HADH;...
Endocrine and other factor-regulated calcium reabsorpti... -1.74 2.81e-2 49/53 (92.45%) PTH1R;ATP1B2;AP2B1;...
Platelet activation -1.75 2.89e-2 106/124 (85.48%) RASGRP2;ADCY6;GP1BA;...
Nitrogen metabolism -1.76 3.37e-2 16/17 (94.12%) CA2;GLUD2;CA9;...
Citrate cycle (TCA cycle) -1.76 3.82e-2 30/30 (100%) ACO1;DLST;IDH1;...
Hepatitis C -1.76 4.50e-2 139/157 (88.54%) NR1H3;CDK2;STAT2;...
Propanoate metabolism -1.85 2.62e-2 30/34 (88.24%) BCKDHB;ACOX1;MMUT;...
Glyoxylate and dicarboxylate metabolism -1.86 3.37e-2 23/30 (76.67%) GLDC;MMUT;ACAT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM - 20uM 6H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 12uM - 30uM 48H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM - 20uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 1.25uM - 100uM 3H, 24H, 48H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM - 20uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H