Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFYAM1)

Drug Name
Enalaprilat Drug Info
Synonyms
Extract of ginger root; Ginger extract; Ginger root extract; Ginger, ext; LS-3194; Zingiber officinale extract; Zingiber officinale root extract; CCRIS 7641; EINECS 283-634-2; FEMA No. 2520; FEMA No. 2521; FEMA No. 2523; Ginger extract (Zingiber officinale); ginger, extract (zingiber officinale rosc.)
Cross-matching ID
PubChem CID
6850776
CAS Number
CAS 84696-15-1
TTD Drug ID
D0N5HJ
INTEDE Drug ID
DR2736

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Fructose and mannose metabolism -1.66 4.18e-2 30/33 (90.91%) HK3;GMPPA;TPI1;...
TNF signaling pathway -1.68 3.65e-2 103/112 (91.96%) BAG4;CXCL10;RIPK1;...
Viral protein interaction with cytokine and cytokine re... -1.69 3.66e-2 84/100 (84%) IL19;IL20RA;TNFSF14;...
Complement and coagulation cascades -1.76 1.87e-2 76/85 (89.41%) CLU;CFHR4;BDKRB1;...
IL-17 signaling pathway -1.77 1.84e-2 84/94 (89.36%) FOS;SRSF1;TRAF3IP2;...
NF-kappa B signaling pathway -1.78 1.33e-2 90/104 (86.54%) EDAR;RIPK1;LTA;...
Sulfur metabolism -1.80 1.18e-2 9/10 (90%) SELENBP1;SQOR;PAPSS2
Aldosterone-regulated sodium reabsorption -1.81 1.18e-2 34/37 (91.89%) PIK3R2;PRKCB;PDPK1;...
Glyoxylate and dicarboxylate metabolism -1.82 1.27e-2 23/30 (76.67%) HAO2;CS;SHMT1;...
Pentose phosphate pathway -1.85 1.07e-2 25/30 (83.33%) PFKP;GPI;PGD;...
Porphyrin and chlorophyll metabolism -1.89 4.70e-3 23/43 (53.49%) GUSB;HMOX2;ALAS1;...
Metabolism of xenobiotics by cytochrome P450 -1.92 2.61e-3 49/77 (63.64%) CYP1A2;CYP2D6;ADH5;...
Tyrosine metabolism -1.92 2.94e-3 30/36 (83.33%) GSTZ1;TPO;GOT2;...
Nitrogen metabolism -1.97 0.00e+0 16/17 (94.12%) CA14;CA8;CPS1;...
Drug metabolism -1.98 0.00e+0 78/151 (51.66%) CYP2C19;CDA;CYP3A5;...
Pyruvate metabolism -1.99 0.00e+0 41/47 (87.23%) ADH5;ACACB;LDHA;...
Bile secretion -1.99 0.00e+0 68/90 (75.56%) SLC9A1;ADCY9;SLC22A7;...
Retinol metabolism -2.02 0.00e+0 41/68 (60.29%) CYP2C8;ALDH1A1;RETSAT;...
Glycolysis / Gluconeogenesis -2.06 0.00e+0 56/67 (83.58%) GPI;ADH5;PFKM;...
Pentose and glucuronate interconversions -2.19 0.00e+0 17/34 (50%) UGDH;GUSB;AKR1B10;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 3.33uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H