Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFYZKN)

• Drug Name: Enprofylline Drug Info
• Synonyms: Enprofilina; Enprofyllinum; Nilyph; Oxeze; P 5679; D-4028; Enprofilina [INN-Spanish]; Enprofylline [USAN:INN]; Enprofyllinum [INN-Latin]; Enprofylline (USAN/INN); 3,7-Dihydro-3-propyl-1H-purine-2,6-dione; 3-Propyl-3,7-dihydro-purine-2,6-dione; 3-Propylxanthine; 3-n-Propylxanthine; 3-propyl-3,7-dihydro-1H-purine-2,6-dione; 3-propyl-7H-purine-2,6-dione
• Therapeutic Class: Antiinflammatory Agents
• Cross-matching ID:
  PubChem CID: 1676
  ChEBI ID: CHEMBL279898
  CAS Number: CAS 41078-02-8
  TTD Drug ID: D09AMZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Mineral absorption	2.21	0.00e+0	48/60 (80%)	MT1F;MT1G;MT1H;...
Tyrosine metabolism	2.17	0.00e+0	30/36 (83.33%)	TYRP1;ADH1B;ALDH3A1;...
Ribosome	2.16	0.00e+0	113/158 (71.52%)	RPS4Y1;RPL26L1;RPS5;...
Type I diabetes mellitus	2.08	0.00e+0	38/43 (88.37%)	PTPRN2;HLA-DRA;HSPD1;...
Parkinson disease	1.97	4.33e-3	176/249 (70.68%)	GNAI1;TXN;UCHL1;...
Oxidative phosphorylation	1.93	3.61e-3	93/133 (69.92%)	ATP5MC2;COX5A;NDUFB5;...
Asthma	1.88	9.28e-3	25/31 (80.65%)	HLA-DRA;HLA-DPA1;HLA-DRB1;...
Antigen processing and presentation	1.86	1.08e-2	60/78 (76.92%)	HLA-DRA;HLA-DPA1;PDIA3;...
Folate biosynthesis	1.85	1.08e-2	23/26 (88.46%)	GGH;PAH;ALPL;...
Proximal tubule bicarbonate reclamation	1.75	3.03e-2	21/23 (91.3%)	SLC4A4;PCK1;GLUD1;...
Allograft rejection	1.75	2.76e-2	32/38 (84.21%)	HLA-DRA;HLA-DPA1;HLA-DRB1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 2.22uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼