Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMFZBNE)

Drug Name
ITF2357 Drug Info
Synonyms Givinostat; Carbamic acid, N-(4-((hydroxyamino)carbonyl)phenyl)-, (6-((diethylamino)methyl)-2-naphthalenyl)methyl ester, hydrochloride (1:1)
Cross-matching ID
PubChem CID
9804992
ChEBI ID
CHEMBL1213492
CAS Number
CAS 497833-27-9
TTD Drug ID
D0GH3Q

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Amoebiasis 2.04 1.24e-2 99/102 (97.06%) FN1;SERPINB9;CD14;...
Hematopoietic cell lineage 1.93 1.24e-2 90/99 (90.91%) HLA-DRA;CD14;CD9;...
Focal adhesion 1.74 4.51e-2 180/201 (89.55%) TNC;FN1;PDGFC;...
Phagosome 1.72 4.56e-2 118/152 (77.63%) HLA-DRA;TUBB2A;C3;...
Ovarian steroidogenesis 1.72 4.10e-2 41/51 (80.39%) ADCY9;PRKACB;PRKACA;...
Gastric acid secretion 1.72 4.07e-2 63/76 (82.89%) ADCY9;PRKACB;PRKACA;...
Pancreatic secretion 1.71 4.25e-2 87/102 (85.29%) CPB1;ADCY9;CPA3;...
Endocrine and other factor-regulated calcium reabsorpti... 1.71 3.92e-2 49/53 (92.45%) ADCY9;PRKACB;PRKACA;...
Carbohydrate digestion and absorption 1.70 4.00e-2 37/47 (78.72%) PIK3R3;FXYD2;ATP1A2;...
Sulfur metabolism 1.69 3.98e-2 9/10 (90%) PAPSS2;PAPSS1;ETHE1
Notch signaling pathway 1.68 3.96e-2 49/59 (83.05%) TLE1;JAG1;HEY1;...
Arrhythmogenic right ventricular cardiomyopathy 1.66 4.83e-2 70/77 (90.91%) LEF1;TCF7L1;ACTB;...
Aldosterone-regulated sodium reabsorption 1.66 4.76e-2 34/37 (91.89%) PIK3R3;FXYD2;ATP1A2;...
Cardiac muscle contraction 1.65 4.97e-2 64/87 (73.56%) FXYD2;ATP1A2;SLC9A6;...
ECM-receptor interaction 1.64 4.91e-2 80/88 (90.91%) TNC;FN1;COL1A1;...
Ribosome -1.76 2.48e-2 113/158 (71.52%) RPS21;RPL22;RPS3A;...
DNA replication -1.76 2.95e-2 34/36 (94.44%) MCM3;RPA2;POLE;...
Ribosome biogenesis in eukaryotes -1.88 6.20e-3 52/108 (48.15%) RIOK2;RRP7A;GTPBP4;...
One carbon pool by folate -1.93 6.20e-3 15/20 (75%) AMT;SHMT1;GART;...
Spliceosome -2.16 0.00e+0 101/150 (67.33%) DDX46;SNRPE;LSM7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Chronic myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HAP1 CVCL_Y019 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 BRD4 (-) 1 CVCL_SF59 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 CDK4 (-) 1 CVCL_SI36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 HDAC5 (-) 1 CVCL_SR11 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 ITGA4 (-) 1 CVCL_ST27 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 MAPK8 (-) 1 CVCL_SW99 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PIK3CA (-) 1 CVCL_TD60 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKACA (-) 1 CVCL_TG70 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 PRKCQ (-) CVCL_TG92 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 RELA (-) 1 CVCL_TI75 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 SRC (-) 1 CVCL_TQ36 Homo sapiens 0.66uM - 3.33uM 24H
HAP1 TP53 (-) 1 CVCL_RJ70 Homo sapiens 0.66uM - 3.33uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.66uM - 10uM 6H, 24H