Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMG0C81)

• Drug Name: Deferoxamine Drug Info
• Synonyms: deferoxamine; Desferrioxamine B; DESFERRIOXAMINE; Deferoxamine B; Deferrioxamine B; 70-51-9; Deferrioxamine; Deferoxamin; Deferoxaminum; DFOM; Desferin; Desferral; Desferrin; Desferex; Desferan; N-Benzoylferrioxamine B; Desferal; DF B; DFOA; Deferoxamide B; Deferoxamina; NSC-527604; Ferrioxamine B, N-benzoyl-; Desferriferrioxamin B; UNII-J06Y7MXW4D; Deferoxamine [USAN:INN]; Deferoxaminum [INN-Latin]; Deferoxamina ; Deferoxamine
• Cross-matching ID:
  PubChem CID: 2973
  ChEBI ID: CHEMBL556
  CAS Number: CAS 70-51-9
  TTD Drug ID: D06GKR

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
mRNA surveillance pathway	1.89	3.91e-2	71/98 (72.45%)	PPP2R5C;FUS;PAPOLA;...
Regulation of actin cytoskeleton	1.86	1.96e-2	185/218 (84.86%)	PDGFRA;IQGAP1;ARHGEF12;...
Proteoglycans in cancer	1.78	3.26e-2	172/205 (83.9%)	IQGAP1;LUM;ARHGEF12;...
Inositol phosphate metabolism	1.75	4.65e-2	66/73 (90.41%)	CDIPT;SACM1L;ALDH6A1;...
Mineral absorption	-1.66	3.78e-2	48/60 (80%)	MT1H;FTL;HMOX2;...
Aminoacyl-tRNA biosynthesis	-1.68	3.47e-2	15/66 (22.73%)	FARS2;NARS2;SARS2;...
RNA polymerase	-1.71	2.68e-2	23/31 (74.19%)	POLR2F;POLR2D;POLR2E;...
Intestinal immune network for IgA production	-1.72	2.52e-2	38/48 (79.17%)	LTBR;PIGR;HLA-DRB1;...
Drug metabolism	-1.72	2.32e-2	78/151 (51.66%)	IMPDH1;CYP2A6;GSTT1;...
Phototransduction	-1.73	2.51e-2	21/29 (72.41%)	CALML3;CALML4;CALML5
Hematopoietic cell lineage	-1.77	2.06e-2	90/99 (90.91%)	CD1B;CD5;IL11;...
Parkinson disease	-1.86	8.26e-3	176/249 (70.68%)	TXN;NDUFA4L2;ATP5F1E;...
Asthma	-1.97	0.00e+0	25/31 (80.65%)	FCER1A;PRG2;HLA-DRB1;...
Pentose and glucuronate interconversions	-1.97	0.00e+0	17/34 (50%)	SORD;XYLB;CRYL1;...
Oxidative phosphorylation	-2.01	0.00e+0	93/133 (69.92%)	LHPP;COX6A2;COX7A2;...
Ribosome	-2.35	0.00e+0	113/158 (71.52%)	RPL35A;RPS28;MRPL22;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	3.33uM	6H	Hide ▲