Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMG0OUD)

Drug Name
GS4071 Drug Info
Synonyms
Oseltamivir acid; 187227-45-8; Oseltamivir carboxylate; Oseltamivir (acid); GS 4071; Ro 64-0802; UNII-K6106LV5Q8; CHEMBL674; CHEBI:73139; K6106LV5Q8; GS-4071; (3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid; 5-N-ACETYL-3-(1-ETHYLPROPYL)-1-CYCLOHEXENE-1-CARBOXYLIC ACID; 1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-, (3R,4R,5S)-; (3r,4r,5s)-4-(Acetylamino)-5-Amino-3-(Pentan-3-Yloxy)cyclohex-1-Ene-1-Carboxylic Acid; G39; Oseltamivir-carboxylate; 2,4-diamino triazine
Cross-matching ID
PubChem CID
449381
ChEBI ID
CHEMBL674
CAS Number
CAS 187227-45-8
TTD Drug ID
D06IDO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Galactose metabolism 2.05 0.00e+0 26/31 (83.87%) PFKL;PFKM;AKR1B1;...
DNA replication 1.92 5.87e-3 34/36 (94.44%) PCNA;PRIM1;MCM6;...
Intestinal immune network for IgA production 1.87 1.17e-2 38/48 (79.17%) CD40;HLA-DQB1;TGFB1;...
Various types of N-glycan biosynthesis 1.87 8.81e-3 26/39 (66.67%) MAN2A1;FUT8;MGAT2;...
Central carbon metabolism in cancer 1.82 1.88e-2 67/70 (95.71%) PFKL;FGFR2;AKT1;...
Fructose and mannose metabolism 1.82 1.57e-2 30/33 (90.91%) PFKL;ALDOB;PFKM;...
Nitrogen metabolism 1.77 3.19e-2 16/17 (94.12%) CA2;GLUD1;GLUD2
Insulin signaling pathway 1.74 4.11e-2 121/137 (88.32%) FASN;SHC1;AKT1;...
Starch and sucrose metabolism 1.73 3.92e-2 25/36 (69.44%) SI;GYG2;ENPP1;...
Protein digestion and absorption 1.72 3.99e-2 78/103 (75.73%) COL6A2;SLC38A2;SLC7A7;...
Glycolysis / Gluconeogenesis 1.71 3.74e-2 56/67 (83.58%) PFKL;ALDH7A1;ALDOB;...
Mismatch repair 1.69 4.41e-2 22/23 (95.65%) PCNA;MSH6;POLD3;...
Folate biosynthesis 1.69 4.07e-2 23/26 (88.46%) GCH1;MOCOS;AKR1B1;...
Base excision repair 1.69 3.78e-2 29/33 (87.88%) PCNA;APEX1;POLE2;...
N-Glycan biosynthesis 1.68 4.07e-2 38/50 (76%) MAN2A1;FUT8;MGAT2;...
NF-kappa B signaling pathway -1.72 4.98e-2 90/104 (86.54%) ZAP70;ATM;GADD45G;...
Legionellosis -1.86 3.69e-2 51/57 (89.47%) NFKB1;NFKBIA;C3;...
Pertussis -2.01 0.00e+0 64/76 (84.21%) MAPK14;NFKB1;TRAF6;...
IL-17 signaling pathway -2.04 0.00e+0 84/94 (89.36%) FOSL1;GSK3B;DEFB4A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H