Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMG1DTE)

Drug Name
Penfluridol Drug Info
Synonyms
PENFLURIDOL; 26864-56-2; Semap; 1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol; TLP-607; McN-JR-16,341; 1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol; Penfluridolum [INN-Latin]; C28H27ClF5NO; UNII-25TLU22Q8H; R 16341; EINECS 248-074-5; R-16341; BRN 1558826; CHEMBL47050; 25TLU22Q8H; MDLAAYDRRZXJIF-UHFFFAOYSA-N; 4-Piperidinol, 1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)-; 4-Piperidinol,; Hydroxamates
Cross-matching ID
PubChem CID
33630
ChEBI ID
CHEMBL47050
CAS Number
CAS 26864-56-2
TTD Drug ID
D0CQ0Z

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Intestinal immune network for IgA production -1.69 4.87e-2 38/48 (79.17%) ITGB7;ITGA4;HLA-DOA;...
Chemokine signaling pathway -1.70 4.92e-2 163/192 (84.9%) CCL24;CXCR2;CXCL1;...
Neutrophil extracellular trap formation -1.72 4.75e-2 101/189 (53.44%) CLEC7A;SYK;MAP2K1;...
Focal adhesion -1.73 4.43e-2 180/201 (89.55%) BAD;GRB2;PIK3CA;...
Collecting duct acid secretion -1.75 3.90e-2 22/27 (81.48%) CA2;CLCNKB;ATP4A;...
Hematopoietic cell lineage -1.78 3.40e-2 90/99 (90.91%) CD38;CD2;CD1E;...
Lysosome -1.81 2.44e-2 115/128 (89.84%) CTSE;AP3D1;NPC1;...
Fc gamma R-mediated phagocytosis -1.83 2.19e-2 79/97 (81.44%) PLA2G6;PLD1;PRKCD;...
Platelet activation -1.84 2.55e-2 106/124 (85.48%) PPP1R12A;ITPR2;TBXA2R;...
Regulation of actin cytoskeleton -1.85 3.06e-2 185/218 (84.86%) IQGAP2;FGF2;PIK3CA;...
Systemic lupus erythematosus -1.86 2.78e-2 45/135 (33.33%) HLA-DOA;HLA-DQB1;HLA-DMB;...
Allograft rejection -1.87 3.71e-2 32/38 (84.21%) PRF1;HLA-DOA;HLA-DQB1;...
Long-term depression -1.93 2.09e-2 55/60 (91.67%) GRM1;GNAZ;PLA2G4A;...
Asthma -2.08 2.78e-2 25/31 (80.65%) FCER1G;HLA-DOA;HLA-DQB1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 30uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 30uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 30uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 30uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 30uM 6H
SNU-C4 CVCL_5008 Homo sapiens 30uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RKO CVCL_0504 Homo sapiens 30uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 30uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 30uM 6H, 24H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 30uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 30uM 6H
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 30uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 30uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 30uM 6H
RMUG-S CVCL_1666 Homo sapiens 30uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 30uM 6H, 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 30uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM - 30uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 30uM 6H