Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMG1FQW)

• Drug Name: IDRA-21 Drug Info
• Synonyms: IDRA-21 analogs; IDRA-5
• Cross-matching ID:
  PubChem CID: 3688
  ChEBI ID: CHEMBL111162
  CAS Number: CAS 22503-72-6
  TTD Drug ID: D0S0VZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Cytosolic DNA-sensing pathway	1.84	4.59e-2	52/63 (82.54%)	CCL5;CASP1;POLR1D;...
Ribosome biogenesis in eukaryotes	1.81	4.08e-2	52/108 (48.15%)	NHP2;FBL;RPP30;...
Type I diabetes mellitus	1.75	4.25e-2	38/43 (88.37%)	PRF1;GZMB;IL1B;...
Allograft rejection	1.74	3.45e-2	32/38 (84.21%)	PRF1;GZMB;IFNG;...
Graft-versus-host disease	1.68	4.80e-2	32/42 (76.19%)	PRF1;GZMB;IL1B;...
Focal adhesion	-1.80	4.37e-2	180/201 (89.55%)	MAPK9;CCND1;MAP2K1;...
ECM-receptor interaction	-1.88	4.03e-2	80/88 (90.91%)	ITGA5;TNC;ITGA3;...
Vibrio cholerae infection	-1.99	1.34e-2	44/50 (88%)	ATP6V1C1;ATP6V1B2;KCNQ1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲