Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMG1OPF)

Drug Name
Buflomedil Drug Info
Synonyms Loftyl; Buflomedil hydrochloride
Cross-matching ID
PubChem CID
2467
ChEBI ID
CHEMBL94538
CAS Number
CAS 55837-25-7
TTD Drug ID
D0Z6ST
INTEDE Drug ID
DR0240

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Intestinal immune network for IgA production -1.61 4.66e-2 38/48 (79.17%) HLA-DRA;IL6;TNFRSF17;...
Leukocyte transendothelial migration -1.64 3.35e-2 90/114 (78.95%) CYBA;CTNNA1;GNAI1;...
Amino sugar and nucleotide sugar metabolism -1.66 3.03e-2 38/48 (79.17%) UGDH;CYB5R3;NPL;...
Cell adhesion molecules -1.69 2.41e-2 118/148 (79.73%) GLG1;SDC4;CD40LG;...
Apoptosis -1.69 2.44e-2 126/168 (75%) FAS;NTRK1;PIK3R1;...
Phagosome -1.70 2.30e-2 118/152 (77.63%) ITGAM;CD209;CYBB;...
Lysosome -1.70 2.44e-2 115/128 (89.84%) ENTPD4;ATP6V0C;MAN2B1;...
Malaria -1.72 2.08e-2 44/50 (88%) CD40LG;MET;TNF;...
Leishmaniasis -1.73 2.09e-2 67/77 (87.01%) ITGAM;CYBB;IFNGR1;...
Pertussis -1.76 1.88e-2 64/76 (84.21%) CD14;C3;SERPING1;...
Complement and coagulation cascades -1.77 1.87e-2 76/85 (89.41%) MBL2;PROC;C3;...
Primary immunodeficiency -1.82 1.06e-2 33/38 (86.84%) CD40LG;CD4;IKBKG;...
Steroid biosynthesis -1.87 6.83e-3 19/20 (95%) LSS;LIPA;HSD17B7;...
Antigen processing and presentation -1.90 5.42e-3 60/78 (76.92%) TNF;CD4;RFXANK;...
Autoimmune thyroid disease -1.93 4.88e-3 46/53 (86.79%) CD40LG;GZMB;HLA-E;...
Asthma -1.95 5.58e-3 25/31 (80.65%) EPX;FCER1G;CD40;...
Systemic lupus erythematosus -2.03 3.25e-3 45/135 (33.33%) CD40LG;C3;C5;...
Viral myocarditis -2.11 0.00e+0 53/60 (88.33%) CD40;SGCB;MYH7;...
Graft-versus-host disease -2.11 0.00e+0 32/42 (76.19%) TNF;GZMB;HLA-E;...
Allograft rejection -2.14 0.00e+0 32/38 (84.21%) FAS;CD40;CD40LG;...
Type I diabetes mellitus -2.18 0.00e+0 38/43 (88.37%) TNF;GZMB;HLA-E;...
Staphylococcus aureus infection -2.22 0.00e+0 72/95 (75.79%) KRT20;FCGR3B;KRT19;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 3.33uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.03uM - 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H