Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMG5BUA)

• Drug Name: (S)-3,4-DCPG Drug Info
• Synonyms: (S)-3,4-dicarboxylphenylglycine
• Cross-matching ID:
  PubChem CID: 16062593
  ChEBI ID: CHEMBL143210
  CAS Number: CAS 201730-11-2
  TTD Drug ID: D0LC5O

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
p53 signaling pathway	1.99	8.17e-3	63/73 (86.3%)	THBS1;CCNE2;CDK1;...
Renin-angiotensin system	-1.70	4.53e-2	20/23 (86.96%)	CPA3;ACE2;THOP1;...
Salivary secretion	-1.73	4.19e-2	76/93 (81.72%)	ADRA1D;ATP1B2;SLC12A2;...
Bladder cancer	-1.74	4.31e-2	40/41 (97.56%)	ARAF;CDH1;CDKN2A;...
Terpenoid backbone biosynthesis	-1.75	4.37e-2	18/22 (81.82%)	MVK;ACAT2;MVD;...
IL-17 signaling pathway	-1.75	4.73e-2	84/94 (89.36%)	CXCL6;IL17B;JUND;...
Fatty acid biosynthesis	-1.79	3.73e-2	16/18 (88.89%)	ACSL6;ACACA;ACSL3;...
GnRH secretion	-1.79	3.99e-2	60/64 (93.75%)	CACNA1I;ARRB1;ESR2;...
Legionellosis	-1.84	2.42e-2	51/57 (89.47%)	C3;CXCL1;CXCL3;...
Cholesterol metabolism	-1.86	2.42e-2	44/50 (88%)	SCARB1;APOC3;APOA4;...
Amoebiasis	-1.87	2.42e-2	99/102 (97.06%)	PTK2;PLCB4;LAMC1;...
Viral protein interaction with cytokine and cytokine re...	-1.92	2.01e-2	84/100 (84%)	IL2RG;CCR6;IL18RAP;...
Rheumatoid arthritis	-1.99	1.45e-2	78/93 (83.87%)	LTB;HLA-DPA1;TNFSF11;...
Biosynthesis of unsaturated fatty acids	-2.01	1.21e-2	21/27 (77.78%)	ELOVL6;ELOVL2;HSD17B4;...
PPAR signaling pathway	-2.15	0.00e+0	66/74 (89.19%)	ACOX2;UBC;FABP1;...
Epithelial cell signaling in Helicobacter pylori infect...	-2.20	0.00e+0	62/70 (88.57%)	JAM3;LYN;CXCR2;...
Steroid biosynthesis	-2.21	0.00e+0	19/20 (95%)	LSS;CYP24A1;CYP51A1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow

Neuroblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
SH-SY5Y	CVCL_0019	Homo sapiens	0.04uM - 10uM	24H	Hide ▲
SK-N-SH	CVCL_0531	Homo sapiens	0.04uM - 10uM	24H	Hide ▲