Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMG6KXB)

• Drug Name: MK-8245 Drug Info
• Synonyms: MK-8245; 1030612-90-8; MK8245; MK 8245; UNII-537E7QE8LX; 537E7QE8LX; CHEMBL1938870; 5-[3-[4-(2-Bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-2H-tetrazole-2-acetic acid; 2H-Tetrazole-2-acetic acid, 5-[3-[4-(2-bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-;2H-Tetrazole-2-acetic acid, 5-[3-[4-(2-bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-; 2-(5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid; UJEAABFSXKCSGI-UHFFFAOYSA-N; C17H16BrFN6O4; MLS006011144
• Cross-matching ID:
  PubChem CID: 24988881
  ChEBI ID: CHEMBL1938870
  CAS Number: CAS 1030612-90-8
  TTD Drug ID: D0S0RS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.26	0.00e+0	19/20 (95%)	MSMO1;SQLE;DHCR24;...
Metabolism of xenobiotics by cytochrome P450	2.24	0.00e+0	49/77 (63.64%)	CYP1B1;HSD11B1;ADH1B;...
Fatty acid degradation	2.19	0.00e+0	40/43 (93.02%)	ACAT2;ADH1B;ADH5;...
Retinol metabolism	2.18	0.00e+0	41/68 (60.29%)	ADH1B;RDH11;ADH5;...
Steroid hormone biosynthesis	2.14	0.00e+0	43/61 (70.49%)	CYP1B1;HSD11B1;AKR1C3;...
Tyrosine metabolism	2.13	0.00e+0	30/36 (83.33%)	ADH1B;ADH5;GOT1;...
Histidine metabolism	2.06	0.00e+0	16/22 (72.73%)	HNMT;HAL;MAOB;...
Glycine, serine and threonine metabolism	2.06	0.00e+0	31/40 (77.5%)	CTH;CBS;PSAT1;...
Tryptophan metabolism	2.04	1.91e-3	35/42 (83.33%)	ACAT2;CYP1B1;KMO;...
PPAR signaling pathway	2.04	1.72e-3	66/74 (89.19%)	SCD;FADS2;SORBS1;...
Biosynthesis of unsaturated fatty acids	1.99	1.56e-3	21/27 (77.78%)	SCD;ELOVL6;ELOVL4;...
Phenylalanine metabolism	1.96	2.14e-3	14/17 (82.35%)	GOT1;MAOB;ALDH3A1;...
Drug metabolism	1.96	1.98e-3	78/151 (51.66%)	ADH1B;GSTA4;ADH5;...
Arginine biosynthesis	1.91	1.84e-3	17/22 (77.27%)	ARG2;GOT1;GLUD2;...
Arachidonic acid metabolism	1.91	2.29e-3	48/61 (78.69%)	PTGIS;GPX2;AKR1C3;...
Complement and coagulation cascades	1.88	3.22e-3	76/85 (89.41%)	TFPI;CFH;FGB;...
Pentose and glucuronate interconversions	1.82	4.54e-3	17/34 (50%)	UGDH;DCXR;UGT2B4;...
Terpenoid backbone biosynthesis	1.81	5.24e-3	18/22 (81.82%)	ACAT2;HMGCR;IDI1;...
Cysteine and methionine metabolism	1.81	4.97e-3	43/50 (86%)	CTH;MAT2B;CDO1;...
Pyruvate metabolism	1.79	5.58e-3	41/47 (87.23%)	ACAT2;ADH1B;ADH5;...
Proteasome	1.78	6.13e-3	44/46 (95.65%)	PSMA3;PSMB8;PSMA4;...
Peroxisome	1.78	5.85e-3	72/82 (87.8%)	ABCD3;IDH1;ACSL4;...
Valine, leucine and isoleucine degradation	1.74	8.58e-3	42/48 (87.5%)	ACAT2;HMGCS1;AOX1;...
Synthesis and degradation of ketone bodies	1.71	1.14e-2	9/10 (90%)	ACAT2;HMGCS1;ACAT1;...
Pantothenate and CoA biosynthesis	1.67	1.92e-2	14/21 (66.67%)	DPYS;PANK3;DPYD;...
Staphylococcus aureus infection	1.67	1.85e-2	72/95 (75.79%)	KRT14;CFH;KRT17;...
Fat digestion and absorption	1.66	2.29e-2	35/43 (81.4%)	ACAT2;APOB;PLPP1;...
Ascorbate and aldarate metabolism	1.65	2.42e-2	15/30 (50%)	UGDH;UGT2B4;UGT2B15;...
Selenocompound metabolism	1.63	2.84e-2	11/17 (64.71%)	CTH;PAPSS2;SEPHS2;...
Fatty acid biosynthesis	1.60	3.30e-2	16/18 (88.89%)	ACSL4;FASN;OXSM;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Hide ▲

Colon

Colon carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCT 116 TP53(-/-)	CVCL_HD97	Homo sapiens	0.04uM - 10uM	24H	Show ▼
HCT 116	CVCL_0291	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Colorectal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCT 116 (Parent)	CVCL_0291	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼