Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMG6OYJ)

Drug Name
Lorcaserin Drug Info
Synonyms APD 356; APD356; AR-10A; (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine; 10-chloro-2-methyl-4-azabicyclo[5.4.0]undeca-8,10,12-triene
Cross-matching ID
PubChem CID
11658860
ChEBI ID
CHEMBL360328
CAS Number
CAS 616202-92-7
TTD Drug ID
D01JMC
INTEDE Drug ID
DR0979
ACDINA Drug ID
D00376

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Biosynthesis of unsaturated fatty acids 2.01 2.34e-2 21/27 (77.78%) ELOVL2;SCD;SCP2;...
Steroid biosynthesis 1.99 1.17e-2 19/20 (95%) SQLE;MSMO1;DHCR7;...
Primary bile acid biosynthesis 1.82 3.90e-2 15/17 (88.24%) SCP2;CH25H;CYP7A1;...
Propanoate metabolism 1.78 4.68e-2 30/34 (88.24%) ACAT2;PCCA;ABAT;...
Leishmaniasis 1.78 3.74e-2 67/77 (87.01%) TLR4;HLA-DQA1;NCF2;...
Tuberculosis 1.76 3.31e-2 159/180 (88.33%) SRC;TLR4;HLA-DQA1;...
Neutrophil extracellular trap formation 1.76 3.01e-2 101/189 (53.44%) SRC;AQP9;TLR4;...
Ribosome biogenesis in eukaryotes -1.86 4.88e-2 52/108 (48.15%) IMP3;XPO1;TBL3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 2.22uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H