Details of the Drug Pharmacogenomic Perturbation Atlas

Cortisone Acetate Drug Info

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID

5745

ChEBI ID

CHEMBL1650

CAS Number

CAS 50-04-4

TTD Drug ID

D0X4RS

INTEDE Drug ID

DR0385

ACDINA Drug ID

D00152

General Information of Drug (ID: DMG8K57)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.47	0.00e+0	34/36 (94.44%)	LIG1;MCM4;FEN1;...
Cell cycle	1.91	1.40e-2	110/124 (88.71%)	PLK1;CDC45;CCNA2;...
Fanconi anemia pathway	1.79	3.97e-2	36/54 (66.67%)	FANCI;RPA3;BLM;...
RNA degradation	1.76	3.86e-2	53/79 (67.09%)	EXOSC4;TOB1;LSM8;...
Nucleotide excision repair	1.75	3.79e-2	40/47 (85.11%)	MNAT1;LIG1;RPA3;...
Spliceosome	1.73	3.50e-2	101/150 (67.33%)	SRSF1;LSM8;HSPA8;...
Primary immunodeficiency	1.70	3.81e-2	33/38 (86.84%)	IL2RG;ICOS;BLNK;...
Homologous recombination	1.69	3.86e-2	35/41 (85.37%)	RAD54B;BRCC3;RPA3;...
Mismatch repair	1.67	4.21e-2	22/23 (95.65%)	LIG1;EXO1;MSH2;...
Pyrimidine metabolism	1.65	4.84e-2	40/56 (71.43%)	NME1;TK1;UPP1;...
Tryptophan metabolism	-1.71	3.95e-2	35/42 (83.33%)	DHTKD1;EHHADH;TPH1;...
Insulin resistance	-1.71	4.30e-2	96/108 (88.89%)	PYGM;PDPK1;MAPK9;...
Pathogenic Escherichia coli infection	-1.72	4.25e-2	152/197 (77.16%)	FOS;PTPN11;GNA12;...
Steroid hormone biosynthesis	-1.72	4.45e-2	43/61 (70.49%)	HSD17B2;HSD17B7;CYP11B2;...
IL-17 signaling pathway	-1.73	4.70e-2	84/94 (89.36%)	TRAF3;CXCL5;MAPK9;...
Malaria	-1.75	4.51e-2	44/50 (88%)	LRP1;THBS4;THBS2;...
Mitophagy	-1.75	4.86e-2	56/68 (82.35%)	MFN1;CSNK2A1;NBR1;...
Amoebiasis	-1.80	4.55e-2	99/102 (97.06%)	PLCB1;ARG2;LAMB3;...
Pertussis	-1.96	4.05e-3	64/76 (84.21%)	NFKB1;MYD88;CASP7;...
Steroid biosynthesis	-2.01	6.07e-3	19/20 (95%)	EBP;FDFT1;LSS;...
Legionellosis	-2.04	0.00e+0	51/57 (89.47%)	NFKB1;MYD88;CASP7;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H

Prostate

Prostate carcinoma

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H