Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMG9B1U)

Drug Name
Elvitegravir Drug Info
Synonyms EVG
Cross-matching ID
PubChem CID
5277135
ChEBI ID
CHEMBL204656
CAS Number
CAS 697761-98-1
TTD Drug ID
D0QD1G
INTEDE Drug ID
DR0570
ACDINA Drug ID
D00227

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 2.20 0.00e+0 44/46 (95.65%) PSMA2;PSME2;PSMB3;...
IL-17 signaling pathway 1.99 1.54e-2 84/94 (89.36%) CXCL5;CXCL1;CXCL8;...
Nucleotide excision repair 1.93 2.05e-2 40/47 (85.11%) RAD23B;MNAT1;PCNA;...
Ribosome 1.87 3.33e-2 113/158 (71.52%) RPS5;RPL35;RPL13;...
Parkinson disease 1.87 2.67e-2 176/249 (70.68%) HSPA5;NDUFA4L2;DAXX;...
One carbon pool by folate 1.81 3.42e-2 15/20 (75%) MTHFD2;TYMS;AMT;...
Nicotinate and nicotinamide metabolism -1.86 4.88e-2 25/35 (71.43%) SIRT1;NNMT;ENPP1;...
Lysosome -1.95 3.90e-2 115/128 (89.84%) HYAL1;AP4M1;ATP6V1H;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H