Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMG9Y80)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.14	0.00e+0	34/36 (94.44%)	MCM6;RFC4;POLE3;...
IL-17 signaling pathway	2.05	0.00e+0	84/94 (89.36%)	CXCL2;CXCL8;CXCL3;...
Mismatch repair	1.89	5.57e-3	22/23 (95.65%)	RFC4;MSH2;LIG1;...
Mineral absorption	1.83	1.67e-2	48/60 (80%)	STEAP1;FXYD2;CYBRD1;...
Epithelial cell signaling in Helicobacter pylori infect...	1.82	1.67e-2	62/70 (88.57%)	CXCL2;CXCL8;CXCL3;...
Nucleotide excision repair	1.81	1.39e-2	40/47 (85.11%)	RAD23B;RFC4;POLE3;...
Drug metabolism	1.72	3.46e-2	78/151 (51.66%)	RRM1;GSTP1;FMO5;...
Cell cycle	1.72	3.03e-2	110/124 (88.71%)	CDK1;TFDP2;CDC45;...
Taurine and hypotaurine metabolism	1.68	4.83e-2	8/11 (72.73%)	ADO;GGT1;GAD1;...
Hypertrophic cardiomyopathy	-1.82	4.70e-2	81/90 (90%)	ITGB1;ITGA7;IL6;...
Dilated cardiomyopathy	-1.99	1.17e-2	86/96 (89.58%)	ITGB1;ITGA7;ITGA2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.04uM - 10uM	24H