Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGBPSH)

Drug Name
Homatropine Methylbromide Drug Info
Synonyms
Arkitropin; Camatropine; Equipin; Esopin; Homapin; Homatromide; Malcotran; Mesopin; Methylhomatropine; Novatrin; Novatrine; Novatropine; Npvatropine; Sethyl; Homatropine methobromide; Homatropine methyl bromide; Homatropini methylbromidum; Humulon lead salt; Methyl Bromide Homatropine; Methylhomatropine bromide; Methylhomatropinum bromatum; Metilbromuro de homatropina; Omatropina metilbromuro; Omatropina metilbromuro [DCIT]; Tropinium methobromide mandelate; DL-Homatropine methyl bromide; DL-Methylbromide; Equipin (TN); Homapin-10; Homapin-5; Homatropine DL-methylbromide; Homatropine methylbromide (USP); Homatropine methylbromide [INN:BAN]; Homatropini methylbromidum [INN-Latin]; Hycodan, probilagol; Isopto Homatropine (TN); Methylbromure d'homatropine; Metilbromuro de homatropina [INN-Spanish]; N-Methylhomatropinium Bromide; Sed-Tems; Methylbromure d'homatropine [INN-French]; HOMATROPINIUM, 8-METHYL-, BROMIDE; [(5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate bromide; (8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate bromide; 3-[2-hydroxy(phenyl)acetoxy]-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide; 3-alpha-Hydroxy-8-methyl-1-alpha-H,5-alpha-H-tropanium bromide mandelate; 3-{[hydroxy(phenyl)acetyl]oxy}-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide; 3alpha-Hydroxy-8-methyl-1alphaH,5alphaH-tropanium bromide mandelate; 8-Methylhomatropinium bromide
Therapeutic ClassAntiulcer Agents
Cross-matching ID
PubChem CID
10429215
CAS Number
CAS 80-49-9
TTD Drug ID
D0O5SZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Antigen processing and presentation 2.19 0.00e+0 60/78 (76.92%) HSPA4;HLA-DQA1;CANX;...
Adherens junction 1.85 4.99e-2 63/71 (88.73%) IQGAP1;TJP1;CDH1;...
Galactose metabolism 1.85 3.69e-2 26/31 (83.87%) PFKP;AKR1B1;PGM1;...
Allograft rejection 1.81 4.15e-2 32/38 (84.21%) HLA-DQA1;HLA-B;HLA-C;...
Fructose and mannose metabolism 1.79 4.65e-2 30/33 (90.91%) PFKP;AKR1B1;PFKFB3;...
Notch signaling pathway 1.78 4.06e-2 49/59 (83.05%) NOTCH2;ATXN1;NCOR2;...
Drug metabolism -1.64 4.13e-2 78/151 (51.66%) UPP1;NAT1;CYP2D6;...
Epithelial cell signaling in Helicobacter pylori infect... -1.74 1.49e-2 62/70 (88.57%) NFKBIA;TCIRG1;MAPK9;...
Mineral absorption -1.74 1.47e-2 48/60 (80%) ATP1A3;ATP1A2;ATP7A;...
Staphylococcus aureus infection -1.75 1.34e-2 72/95 (75.79%) HLA-DQB1;SELPLG;KRT24;...
AGE-RAGE signaling pathway in diabetic complications -1.77 1.31e-2 97/100 (97%) EDN1;CDC42;PIK3R1;...
Steroid hormone biosynthesis -1.77 1.40e-2 43/61 (70.49%) CYP17A1;HSD17B3;HSD17B8;...
African trypanosomiasis -1.78 1.30e-2 32/37 (86.49%) IL6;HPR;APOA1;...
Cytokine-cytokine receptor interaction -1.84 7.44e-3 246/295 (83.39%) INHBE;CCR5;PPBP;...
Legionellosis -1.87 7.30e-3 51/57 (89.47%) CR1;RAB1B;BNIP3;...
Amoebiasis -1.92 2.68e-3 99/102 (97.06%) LAMC3;LAMC2;C8A;...
Metabolism of xenobiotics by cytochrome P450 -1.94 1.98e-3 49/77 (63.64%) GSTK1;GSTO1;UGT2B4;...
Pertussis -2.07 0.00e+0 64/76 (84.21%) ITGB2;C3;PYCARD;...
TNF signaling pathway -2.07 0.00e+0 103/112 (91.96%) BCL3;ATF2;EDN1;...
Malaria -2.11 0.00e+0 44/50 (88%) GYPC;THBS3;CSF3;...
NF-kappa B signaling pathway -2.13 0.00e+0 90/104 (86.54%) LTB;LY96;IL1R1;...
Rheumatoid arthritis -2.19 0.00e+0 78/93 (83.87%) IL6;MMP3;MMP1;...
Viral protein interaction with cytokine and cytokine re... -2.27 0.00e+0 84/100 (84%) CCR5;PPBP;CCL11;...
IL-17 signaling pathway -2.32 0.00e+0 84/94 (89.36%) NFKBIA;MAPK9;GSK3B;...
Complement and coagulation cascades -2.47 0.00e+0 76/85 (89.41%) CR1;MASP2;C1QB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H