Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGC5DB)

Drug Name
Ciprofibrate Drug Info
Synonyms
Ciprofibrato; Ciprofibratum; Ciprol; Hiperlipen; Hyperlipen; Lipanor; Modalim; Oroxadin; Sanofi Synthelabo brand of ciprofibrate; Sanofi Winthrop brand of ciprofibrate; C 0330; WIN 35833; Ciprofibrato [INN-Spanish]; Ciprofibratum [INN-Latin]; Win 35,833; Win-35833; Ciprofibrate (USAN/INN); Ciprofibrate [USAN:BAN:INN]; 2-(4-(2,2-Dichlorocyclopropyl)phenoxy)2-methylpropanoic acid; 2-(p-(2,2-Dichlorocyclopropyl)phenoxy)-2-methylpropionic acid; 2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid; 2-[p-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid; 2-{4-[2,2-dichlorocyclopropyl]phenoxy}-2-methylpropanoic acid; 2-{[4-(2,2-dichlorocyclopropyl)phenyl]oxy}-2-methylpropanoic acid
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
2763
ChEBI ID
CHEMBL50867
CAS Number
CAS 52214-84-3
TTD Drug ID
D0EJ6O
VARIDT Drug ID
DR01188
INTEDE Drug ID
DR0330

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
mRNA surveillance pathway 1.97 3.02e-2 71/98 (72.45%) PPP2R5E;GSPT2;CSTF2T;...
Steroid biosynthesis -1.74 4.11e-2 19/20 (95%) FDFT1;EBP;SOAT2;...
Primary immunodeficiency -1.80 2.81e-2 33/38 (86.84%) CD19;TNFRSF13B;CD79A;...
Dilated cardiomyopathy -1.80 3.38e-2 86/96 (89.58%) ITGB7;LAMA2;TNF;...
Hypertrophic cardiomyopathy -1.95 2.48e-3 81/90 (90%) ITGB7;LAMA2;TNF;...
Cardiac muscle contraction -2.00 0.00e+0 64/87 (73.56%) CACNA1S;TRDN;TPM2;...
Vibrio cholerae infection -2.02 0.00e+0 44/50 (88%) SEC61A2;ATP6V0D1;PRKACG;...
Mineral absorption -2.21 0.00e+0 48/60 (80%) TRPV6;VDR;FXYD2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.66uM - 20uM 3H, 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H