Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGCHDS)

• Drug Name: Sulfamethizole Drug Info
• Synonyms: Ayerlucil; Famet; Lucosil; Methazol; Microsul; Proklar; Renasul; Rufol; SULFAMETHIAZOLE; Salimol; Solfametizolo; Sulamethizole; Sulfamethazole; Sulfamethizol; Sulfamethizolum; Sulfamethylthiadiazole; Sulfametizol; Sulfapyelon; Sulfstat; Sulfurine; Sulphamethizole; Sulphamethyltiadiazole; Tetracid; Thidicur;Thiosulfil; Ultrasul; Urocydal; Urodiaton; Urolucosil; Urosulfin; Uroz; Solfametizolo [DCIT]; Sulfa gram; Thiosulfil Forte; RP 2145; VK 53; Sulfamethizolum [INN-Latin]; Sulfametizol [INN-Spanish]; Thiosulfil (TN); Sulfamethizole [USAN:INN:JAN]; Thiosulfil-A-Forte; Sulfamethizole (JP15/USP/INN); N1-(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanilamide; N(1)-(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanilamide; N(sup 1)-(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanilamide; N(sup 1)-(5-Methyl-1,3,4-thiadiazol-2-yl)-sulfanilamide; 2-(p-Aminobenzenesulfonamido)-5-methylthiadiazole; 2-Methyl-5-sulfanilamido-1,3,4-thiadiazole; 2-Sulfanilamido-5-methyl-1,3,4-thiadiazole; 4-Amino-N-(5-Methyl-1,3,4-Thiadiazol-2-Yl)Benzene-1-Sulfonamide; 4-Amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide; 4-Amino-N-[5-methyl-1,3,4-thiadiazol-2-yl]benzenesulfonamide; 5-Methyl-2-sulfanilamido-1,3,4-thiadiazole
• Therapeutic Class: Antiinfective Agents
• Cross-matching ID:
  PubChem CID: 5328
  ChEBI ID: CHEMBL1191
  CAS Number: CAS 144-82-1
  TTD Drug ID: D07JJS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Viral protein interaction with cytokine and cytokine re...	2.18	0.00e+0	84/100 (84%)	CXCL13;CXCL9;CCL5;...
Retinol metabolism	2.03	0.00e+0	41/68 (60.29%)	ALDH1A1;CYP3A4;CYP3A7;...
Fatty acid degradation	1.93	1.05e-2	40/43 (93.02%)	ACAT2;ACAA2;EHHADH;...
Primary immunodeficiency	1.84	2.90e-2	33/38 (86.84%)	CD8A;CD8B;CD40;...
Drug metabolism	1.83	2.32e-2	78/151 (51.66%)	CYP3A4;UGT2A3;DUT;...
Pyrimidine metabolism	1.73	4.97e-2	40/56 (71.43%)	DUT;RRM2;CTPS1;...
Oxidative phosphorylation	1.68	4.96e-2	93/133 (69.92%)	ATP5MC1;NDUFB1;SDHC;...
Chemokine signaling pathway	1.67	4.83e-2	163/192 (84.9%)	CXCL13;CXCL9;CCL5;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼