Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGDA3C)

Drug Name
cycloheximide Drug Info
Synonyms naramycin A; NSC 185; FT 3422-2; NM-MCD 80
Cross-matching ID
PubChem CID
6197
ChEBI ID
CHEMBL123292
CAS Number
CAS 66-81-9
TTD Drug ID
D06ZWX
VARIDT Drug ID
DR01367

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
NF-kappa B signaling pathway 2.07 0.00e+0 90/104 (86.54%) GADD45B;RELB;NFKBIA;...
TNF signaling pathway 1.92 1.42e-2 103/112 (91.96%) JUN;CCL2;NFKBIA;...
Circadian rhythm 1.88 1.90e-2 26/31 (83.87%) PER2;RBX1;CRY1;...
Complement and coagulation cascades 1.84 1.90e-2 76/85 (89.41%) F3;SERPINB2;CD55;...
AGE-RAGE signaling pathway in diabetic complications 1.81 2.66e-2 97/100 (97%) EGR1;JUN;F3;...
IL-17 signaling pathway 1.81 2.21e-2 84/94 (89.36%) S100A8;JUN;CCL2;...
Cell cycle 1.77 2.85e-2 110/124 (88.71%) GADD45B;WEE1;GADD45A;...
Basal transcription factors 1.77 2.85e-2 37/45 (82.22%) TAF2;TAF9;CCNH;...
Malaria 1.73 3.69e-2 44/50 (88%) CCL2;CXCL8;ICAM1;...
Sulfur metabolism -1.64 4.72e-2 9/10 (90%) ETHE1;SELENBP1;TST;...
Pyruvate metabolism -1.66 4.24e-2 41/47 (87.23%) MDH1;GLO1;ACACA;...
Primary immunodeficiency -1.66 4.36e-2 33/38 (86.84%) IL2RG;PTPRC;RFXAP;...
Pentose and glucuronate interconversions -1.71 2.62e-2 17/34 (50%) UGP2;UGDH;UGT2A3;...
Terpenoid backbone biosynthesis -1.73 1.99e-2 18/22 (81.82%) MVD;DHDDS;ICMT;...
Amino sugar and nucleotide sugar metabolism -1.75 1.70e-2 38/48 (79.17%) CYB5R2;PGM1;GNE;...
Ferroptosis -1.77 1.44e-2 36/41 (87.8%) ACSL3;SLC11A2;GCLC;...
Pentose phosphate pathway -1.80 6.52e-3 25/30 (83.33%) TKT;ALDOA;TALDO1;...
Other types of O-glycan biosynthesis -1.81 7.07e-3 29/47 (61.7%) C1GALT1;POMT2;LFNG;...
Glycolysis / Gluconeogenesis -1.81 7.71e-3 56/67 (83.58%) PGM1;PCK1;ADPGK;...
Other glycan degradation -1.84 5.30e-3 13/18 (72.22%) MAN2B1;MAN2B2;HEXB;...
Glycosaminoglycan degradation -1.84 5.89e-3 19/19 (100%) IDUA;HYAL2;HGSNAT;...
Porphyrin and chlorophyll metabolism -1.85 6.62e-3 23/43 (53.49%) ALAS2;HMOX2;ALAD;...
Cysteine and methionine metabolism -1.98 0.00e+0 43/50 (86%) DNMT3A;DNMT3B;LDHA;...
Various types of N-glycan biosynthesis -1.99 0.00e+0 26/39 (66.67%) B4GALT2;MAN2A1;RPN1;...
Folate biosynthesis -2.07 0.00e+0 23/26 (88.46%) DHFR;TPH1;PCBD1;...
Lysosome -2.16 0.00e+0 115/128 (89.84%) ARSA;AP1G2;NPC2;...
Steroid biosynthesis -2.26 0.00e+0 19/20 (95%) DHCR24;TM7SF2;HSD17B7;...
Protein processing in endoplasmic reticulum -2.50 0.00e+0 127/171 (74.27%) EIF2AK3;ERO1A;SEC24D;...
Antigen processing and presentation -2.53 0.00e+0 60/78 (76.92%) TAP2;HLA-DPB1;CTSB;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM - 12.5uM 6H, 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 2.5uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 2.5uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.37uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H