Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGHLG5)

Drug Name
Withaferin A Drug Info
Synonyms Heat shock factor 1 inhibitor (melanoma), University of Kansas; HSF-1 inhibitor (melanoma), University of Kansas
Cross-matching ID
PubChem CID
265237
ChEBI ID
CHEMBL517080
CAS Number
CAS 5119-48-2
TTD Drug ID
D0V3PN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
IL-17 signaling pathway 2.22 0.00e+0 84/94 (89.36%) FOSL1;FOS;FOSB;...
Estrogen signaling pathway 2.14 0.00e+0 119/137 (86.86%) HSPA6;HSPA1A;FOS;...
Protein processing in endoplasmic reticulum 2.11 0.00e+0 127/171 (74.27%) HSPA6;HSPA1A;DNAJB1;...
Legionellosis 2.11 0.00e+0 51/57 (89.47%) HSPA6;HSPA1A;HSPA8;...
Mineral absorption 2.08 0.00e+0 48/60 (80%) HMOX1;FTH1;MT1M;...
Proteasome 2.04 2.18e-3 44/46 (95.65%) ADRM1;PSMD11;PSMC5;...
Antigen processing and presentation 2.01 1.87e-3 60/78 (76.92%) HSPA6;HSPA1A;HSPA8;...
Spliceosome 1.95 4.90e-3 101/150 (67.33%) HSPA6;HSPA1A;HSPA8;...
Longevity regulating pathway 1.91 5.81e-3 90/151 (59.6%) HSPA6;HSPA1A;HSPA8;...
Ferroptosis 1.91 5.23e-3 36/41 (87.8%) HMOX1;FTH1;SLC3A2;...
Lipid and atherosclerosis 1.85 1.19e-2 190/215 (88.37%) HSPA6;HSPA1A;FOS;...
Osteoclast differentiation 1.81 1.63e-2 117/127 (92.13%) FOSL1;FOS;FOSB;...
Parathyroid hormone synthesis, secretion and action 1.80 1.61e-2 98/106 (92.45%) EGR1;FOS;HBEGF;...
MAPK signaling pathway 1.77 2.33e-2 272/294 (92.52%) HSPA6;HSPA1A;GADD45B;...
Amphetamine addiction 1.76 2.27e-2 57/69 (82.61%) FOS;FOSB;ARC;...
Fluid shear stress and atherosclerosis 1.75 2.29e-2 123/139 (88.49%) HMOX1;FOS;JUN;...
NF-kappa B signaling pathway 1.71 3.46e-2 90/104 (86.54%) GADD45B;GADD45A;CXCL8;...
Spinocerebellar ataxia 1.71 3.27e-2 128/143 (89.51%) ADRM1;PSMD11;PPIF;...
Pertussis 1.70 3.65e-2 64/76 (84.21%) FOS;JUN;SERPING1;...
Apoptosis 1.68 4.84e-2 126/168 (75%) GADD45B;FOS;DDIT3;...
Tryptophan metabolism -1.62 4.84e-2 35/42 (83.33%) EHHADH;ALDH1B1;GCDH;...
Thermogenesis -1.62 4.55e-2 173/232 (74.57%) ATP5F1B;NDUFB11;PRKACB;...
Butanoate metabolism -1.62 4.86e-2 23/28 (82.14%) EHHADH;ACSM3;L2HGDH;...
Ribosome -1.66 4.01e-2 113/158 (71.52%) RPL18;MRPL13;RPL36A;...
Fatty acid biosynthesis -1.66 4.31e-2 16/18 (88.89%) ACSL6;ACSL1;ACACA;...
Nitrogen metabolism -1.67 4.31e-2 16/17 (94.12%) GLUD1;GLUD2;CA12;...
Fatty acid elongation -1.70 3.11e-2 19/27 (70.37%) ECHS1;ELOVL5;HACD2;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -1.71 3.21e-2 20/26 (76.92%) PIGF;PGAP1;PIGN;...
Pyruvate metabolism -1.80 1.38e-2 41/47 (87.23%) ACACA;ALDH1B1;HAGH;...
Renin-angiotensin system -1.80 1.46e-2 20/23 (86.96%) ACE2;PREP;CPA3;...
Peroxisome -1.91 5.20e-3 72/82 (87.8%) DECR2;HMGCL;AGPS;...
Propanoate metabolism -1.92 6.07e-3 30/34 (88.24%) HIBCH;EHHADH;ACACA;...
Citrate cycle (TCA cycle) -1.92 5.83e-3 30/30 (100%) PCK1;ACO1;IDH2;...
Diabetic cardiomyopathy -1.98 1.82e-3 162/203 (79.8%) ATP5F1B;NDUFB11;ATP5PD;...
Valine, leucine and isoleucine degradation -2.06 2.43e-3 42/48 (87.5%) DBT;ACAA1;HADHA;...
Oxidative phosphorylation -2.15 3.64e-3 93/133 (69.92%) ATP5F1B;NDUFB11;ATP5PD;...
Fatty acid degradation -2.24 0.00e+0 40/43 (93.02%) ADH6;ECI2;ECHS1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.37uM - 20uM 6H, 24H
Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
SK-N-SH CVCL_0531 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 20uM 3H, 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.04uM - 10uM 3H, 24H
SK-BR-3 CVCL_0033 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-20 CVCL_0178 Homo sapiens 0.04uM - 10uM 3H, 24H
Hs 578T CVCL_0332 Homo sapiens 0.04uM - 10uM 3H, 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 3H, 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.04uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 20uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 20uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 0.04uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 20uM 3H, 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 20uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 20uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 0.04uM - 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 0.04uM - 10uM 24H
WI-38 CVCL_0579 Homo sapiens 0.04uM - 10uM 24H
Peripheral blood
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
LNCaP CVCL_0395 Homo sapiens 0.04uM - 10uM 3H, 24H
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 1.11uM - 20uM 6H, 24H, 48H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 6H, 24H
Unclear
Rat sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
XC CVCL_1891 Rattus norvegicus (Rat) 10uM 24H