Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGINBT)

• Drug Name: SGC707 Drug Info
• Synonyms: 1687736-54-4; SGC 707; SGC-707; 1-Isoquinolin-6-Yl-3-[2-Oxo-2-(Pyrrolidin-1-Yl)ethyl]urea; GTPL8552; KS-00000THM; AOB5757; MolPort-039-101-300; EX-A1304; BCP16746; s7832; ZINC220951188; AKOS025142099; CS-5370; ACN-053041; NCGC00384204-04; HY-19715; AK546586; SGC707, > AS-16917; FT-0700238; J-690235; 1-isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea; 1-(isoquinolin-6-yl)-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea; 1-(Isoquinolin-6-yl)-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl] urea
• Cross-matching ID:
  PubChem CID: 90642938
  ChEBI ID: CHEMBL4072005
  TTD Drug ID: D00JWB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Spliceosome	2.07	0.00e+0	101/150 (67.33%)	SRSF1;HNRNPM;FUS;...
DNA replication	2.04	0.00e+0	34/36 (94.44%)	PCNA;RPA2;RNASEH2A;...
Ribosome biogenesis in eukaryotes	1.89	1.36e-2	52/108 (48.15%)	NOP56;RAN;FBL;...
Inflammatory mediator regulation of TRP channels	1.87	1.36e-2	82/98 (83.67%)	SRC;IL1R1;ADCY1;...
GnRH signaling pathway	1.84	1.36e-2	80/93 (86.02%)	SRC;CDC42;ADCY1;...
Nitrogen metabolism	1.79	2.03e-2	16/17 (94.12%)	CA2;GLUD2;GLUD1;...
Oocyte meiosis	1.76	3.29e-2	90/129 (69.77%)	CDC20;ESPL1;ADCY1;...
Mismatch repair	1.74	3.56e-2	22/23 (95.65%)	PCNA;RPA2;EXO1;...
Non-homologous end-joining	1.72	4.22e-2	11/13 (84.62%)	DCLRE1C;XRCC5;RAD50;...
Adherens junction	1.71	3.79e-2	63/71 (88.73%)	SRC;SORBS1;CDC42;...
Regulation of lipolysis in adipocytes	1.70	4.19e-2	52/55 (94.55%)	PLIN1;ADCY1;ADCY9;...
Fat digestion and absorption	1.69	4.29e-2	35/43 (81.4%)	CD36;APOA1;ABCA1;...
Galactose metabolism	1.68	4.69e-2	26/31 (83.87%)	AKR1B10;UGP2;SI;...
Melanogenesis	1.67	4.65e-2	74/101 (73.27%)	ADCY1;ADCY9;FZD5;...
Progesterone-mediated oocyte maturation	1.67	4.43e-2	75/100 (75%)	ADCY1;ADCY9;CDC25A;...
Viral carcinogenesis	1.66	4.74e-2	149/203 (73.4%)	SRC;CDC20;CDC42;...
RNA transport	1.65	4.54e-2	128/186 (68.82%)	PRMT5;FUS;EIF4A1;...
Steroid biosynthesis	-1.84	2.50e-2	19/20 (95%)	DHCR7;CYP24A1;DHCR24;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Hide ▲

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Show ▼