Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGIR3F)

Drug Name
P5091 Drug Info
Synonyms
882257-11-6; P005091; 1-(5-(2,3-dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone; P-5091; 1-[5-(2,3-Dichloro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone; CHEMBL2159495; P5091 (P005091); 1-[5-(2,3-dichlorophenyl)sulfanyl-4-nitrothiophen-2-yl]ethanone; 1-(5-((2,3-Dichlorophenyl)thio)-4-nitrothiophen-2-yl)ethanone; Cyto5D7; C12H7Cl2NO3S2; SCHEMBL2681288; DTXSID90384841; 1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]ethanone; HMS3653E09; HMS3743M19; ZINC125366; BCP07750; EX-A2120; BDBM50393437; MFCD00123202; s7132; AKOS024458314; CCG-240421; CS-1445; MCULE-6661883192; QC-8200; SB19505; AC-32692; AK270202; BS-17872; DA-40897; HY-15667; FT-0714931; SW219710-1; Y1893; J3.502.625H; P 5091; P-05091; P005091(P5091); P 005091; P-005091; 1-[5-(2,3-dichlorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone; 1-[5-(2,3-dichlorophenylsulfanyl)-4-nitro-2-thienyl]ethanone; 1-[5-[(2,3-Dichlorophenyl)thio]-4-n?itro-2-thienyl]ethanone; 1-{5-[(2,3-Dichlorophenyl)sulfanyl]-4-nitrothiophen-2-yl}ethan-1-one
Cross-matching ID
PubChem CID
2819993
ChEBI ID
CHEMBL2159495
CAS Number
CAS 882257-11-6
TTD Drug ID
DV3KC5

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Legionellosis 2.41 0.00e+0 51/57 (89.47%) HSPA1A;BNIP3;IL6;...
Viral protein interaction with cytokine and cytokine re... 2.40 0.00e+0 84/100 (84%) CCL19;IL6;CCR7;...
Mineral absorption 2.38 0.00e+0 48/60 (80%) HMOX1;MT1F;MT1H;...
Cytokine-cytokine receptor interaction 2.38 0.00e+0 246/295 (83.39%) CCL19;IL6;CCR7;...
IL-17 signaling pathway 2.31 0.00e+0 84/94 (89.36%) S100A9;S100A7;IL6;...
Ferroptosis 2.30 0.00e+0 36/41 (87.8%) HMOX1;GCLM;FTH1;...
PPAR signaling pathway 2.17 0.00e+0 66/74 (89.19%) PLIN2;SCD;ACSL1;...
Rheumatoid arthritis 2.14 0.00e+0 78/93 (83.87%) IL6;CCL20;TLR4;...
NF-kappa B signaling pathway 2.12 0.00e+0 90/104 (86.54%) CCL19;TLR4;BCL2A1;...
Steroid biosynthesis 2.10 2.48e-3 19/20 (95%) DHCR24;SOAT1;SQLE;...
Pertussis 2.03 2.25e-3 64/76 (84.21%) IL6;TLR4;MAPK13;...
Measles 2.02 2.06e-3 133/139 (95.68%) HSPA1A;IL6;TLR4;...
Biosynthesis of unsaturated fatty acids 1.95 1.91e-3 21/27 (77.78%) FADS1;SCD;HACD1;...
Chagas disease 1.94 1.77e-3 93/102 (91.18%) IL6;TLR4;MAPK13;...
HIF-1 signaling pathway 1.91 2.48e-3 105/109 (96.33%) HMOX1;PFKP;CDKN1A;...
Toll-like receptor signaling pathway 1.88 3.10e-3 94/104 (90.38%) IL6;TLR4;MAPK13;...
Tuberculosis 1.87 3.64e-3 159/180 (88.33%) IL6;TLR4;MAPK13;...
Shigellosis 1.87 3.44e-3 180/246 (73.17%) BNIP3;SQSTM1;TLR4;...
Epithelial cell signaling in Helicobacter pylori infect... 1.85 3.26e-3 62/70 (88.57%) MAPK13;CXCL1;JUN;...
Osteoclast differentiation 1.79 8.05e-3 117/127 (92.13%) SQSTM1;MAPK13;FOSL1;...
Hematopoietic cell lineage 1.77 1.00e-2 90/99 (90.91%) ANPEP;IL6;MS4A1;...
Lipid and atherosclerosis 1.77 1.01e-2 190/215 (88.37%) HSPA1A;IL6;TLR4;...
JAK-STAT signaling pathway 1.75 1.24e-2 146/162 (90.12%) CDKN1A;IL6;SOCS1;...
TNF signaling pathway 1.74 1.19e-2 103/112 (91.96%) IL6;CCL20;MAPK13;...
p53 signaling pathway 1.74 1.14e-2 63/73 (86.3%) CDKN1A;SFN;CCNB1;...
Cytosolic DNA-sensing pathway 1.73 1.48e-2 52/63 (82.54%) IL6;POLR2H;IKBKG;...
NOD-like receptor signaling pathway 1.72 1.61e-2 145/181 (80.11%) IL6;TLR4;MAPK13;...
Collecting duct acid secretion 1.71 1.68e-2 22/27 (81.48%) CA2;ATP6V0E1;ATP6V1C1;...
Chemokine signaling pathway 1.71 1.62e-2 163/192 (84.9%) CCL19;CCR7;CCL20;...
Yersinia infection 1.70 1.77e-2 120/137 (87.59%) IL6;TLR4;MAPK13;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H