Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGKIYE)

• Drug Name: EPIDEPRIDE Drug Info
• Synonyms: Epidepride; CHEMBL44237; 107188-87-4; N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-5-iodo-2,3-dimethoxybenzamide; AC1L3AWQ; SCHEMBL8961795; DTXSID00147929; CHEBI:125687; N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-iodo-2,3-dimethoxybenzamide; BDBM50008782; PDSP2_001484; BRD-K99502674-001-01-5; (s)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-iodo-2,3-dimethoxy-benzamide; N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5-iodo-2,3-dimethoxy-benzamide (epidepride); Epidepride;N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5-iodo-2,3-dimethoxy-benzamide; Benzamide, N-((1-
• Cross-matching ID:
  PubChem CID: 86101
  ChEBI ID: CHEMBL125687
  CAS Number: CAS 107188-87-4
  TTD Drug ID: D0C8WL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	1.98	2.28e-2	34/36 (94.44%)	MCM5;MCM6;POLE2;...
IL-17 signaling pathway	1.91	2.28e-2	84/94 (89.36%)	CCL20;CXCL1;IL17RB;...
Rheumatoid arthritis	1.85	2.02e-2	78/93 (83.87%)	CCL20;CXCL1;MMP3;...
TNF signaling pathway	1.81	3.04e-2	103/112 (91.96%)	CCL20;CXCL1;CASP10;...
Viral protein interaction with cytokine and cytokine re...	1.77	4.71e-2	84/100 (84%)	CCL20;CXCL1;CXCL5;...
Base excision repair	1.75	4.93e-2	29/33 (87.88%)	POLE2;NEIL3;PCNA;...
Citrate cycle (TCA cycle)	-1.86	3.15e-2	30/30 (100%)	OGDHL;PCK2;IDH1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Hide ▲