Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGL19D)

Drug Name
Enzalutamide Drug Info
Synonyms MDV3100; Enzalutamide (AR inhibitor)
Cross-matching ID
PubChem CID
15951529
ChEBI ID
CHEMBL1082407
CAS Number
CAS 915087-33-1
TTD Drug ID
D0QK5X
ACDINA Drug ID
D01051

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.02 1.06e-2 34/36 (94.44%) MCM2;MCM5;MCM6;...
Pyrimidine metabolism 1.98 5.30e-3 40/56 (71.43%) CTPS1;TYMS;DPYD;...
Cell cycle 1.81 4.60e-2 110/124 (88.71%) CDC20;MCM2;MCM5;...
Mitophagy -1.73 4.71e-2 56/68 (82.35%) OPTN;EIF2AK3;ATG5;...
Non-alcoholic fatty liver disease -1.77 3.92e-2 126/155 (81.29%) EIF2S1;NDUFB3;COX7A2L;...
Mineral absorption -1.80 3.01e-2 48/60 (80%) MT1H;ATP1B3;S100G;...
Steroid biosynthesis -1.82 2.82e-2 19/20 (95%) TM7SF2;FDFT1;EBP;...
Ferroptosis -2.02 0.00e+0 36/41 (87.8%) STEAP3;GCLM;GSS;...
Oxidative phosphorylation -2.20 0.00e+0 93/133 (69.92%) ATP6V0D1;ATP6V1E1;NDUFB2;...
Porphyrin and chlorophyll metabolism -2.38 0.00e+0 23/43 (53.49%) HMOX2;UGT2B28;HEPH;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 0.25uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 0.25uM 6H
HT-29 CVCL_0320 Homo sapiens 0.03uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 0.25uM 6H
MDST8 CVCL_1400 Homo sapiens 0.25uM 6H
NCI-H508 CVCL_1561 Homo sapiens 0.25uM 6H
SNU-1040 CVCL_5001 Homo sapiens 0.25uM 6H
SNU-C4 CVCL_5008 Homo sapiens 0.25uM 6H
SNU-C5 CVCL_5009 Homo sapiens 0.25uM 6H
SW480 CVCL_0546 Homo sapiens 0.25uM 6H
SW620 CVCL_0547 Homo sapiens 0.25uM 6H
SW948 CVCL_0550 Homo sapiens 0.25uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 0.25uM 6H
HT115 CVCL_1294 Homo sapiens 0.25uM 6H
RKO CVCL_0504 Homo sapiens 0.25uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.25uM 6H
SNG-M CVCL_1707 Homo sapiens 0.25uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 0.25uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.25uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 0.25uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 0.25uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 0.25uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 0.25uM 6H
T3M-10 CVCL_1729 Homo sapiens 0.25uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 0.25uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 0.25uM 6H
HCC515 CVCL_5134 Homo sapiens 0.25uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 0.25uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 0.25uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 0.25uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 0.25uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 0.25uM 6H
OV7 CVCL_1623 Homo sapiens 0.25uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 0.25uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 0.25uM 6H
RMUG-S CVCL_1666 Homo sapiens 0.25uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 0.25uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 0.25uM 6H
PL-21 CVCL_2161 Homo sapiens 0.25uM 6H
SKM-1 CVCL_0010 Homo sapiens 0.25uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 0.25uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.66uM - 20uM 24H
C4-2 CVCL_4782 Homo sapiens 0.66uM - 20uM 24H
DU 145 CVCL_0105 Homo sapiens 0.66uM - 20uM 24H
LNCaP CVCL_0395 Homo sapiens 0.66uM - 20uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 20uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.25uM - 20uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 0.25uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 0.25uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.25uM 6H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.04uM - 10uM 24H