Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGLZ26)

Drug Name
Practolol Drug Info
Synonyms
Dalzic; Eraldin; Practololo; Practololum; Praktololu; Teranol; Eralzdin Practolol; Practololo [DCIT]; Praktololu [Polish]; AY 21011; Cardiol (TN); Cordialina (TN); Dalzic (TN); Eraldin (TN); Eraldina (TN); Practololum [INN-Latin]; Praktol (TN); Pralon (TN); Teranol (TN); Practolol [USAN:BAN:INN]; N-{4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}acetamide; N-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide; N-[4-({2-hydroxy-3-[(1-methylethyl)amino]propyl}oxy)phenyl]acetamide; N-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide; N-(4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamide; (+-)-Practolol; 1-(4-Acetamidophenoxy)-3-isopropylamino-2-propanol; 4'-(2-Hydroxy-3-(isopropylamino)propoxy)acetanilide
Therapeutic ClassAntiarrhythmic Agents
Cross-matching ID
PubChem CID
4883
ChEBI ID
CHEMBL6995
CAS Number
CAS 6673-35-4
TTD Drug ID
D0KD1U
INTEDE Drug ID
DR1318

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Viral protein interaction with cytokine and cytokine re... 2.02 0.00e+0 84/100 (84%) CXCL5;CXCL1;CCL5;...
TNF signaling pathway 2.01 0.00e+0 103/112 (91.96%) CXCL5;CXCL1;SELE;...
Focal adhesion 1.76 4.98e-2 180/201 (89.55%) LAMB1;SRC;COL1A2;...
Notch signaling pathway 1.74 4.74e-2 49/59 (83.05%) HEY1;JAG1;TLE4;...
Cell cycle 1.73 4.34e-2 110/124 (88.71%) CDC45;ANAPC5;TGFB3;...
DNA replication 1.71 4.83e-2 34/36 (94.44%) LIG1;FEN1;MCM2;...
Pathways in cancer 1.71 4.49e-2 474/531 (89.27%) LAMB1;MECOM;PTCH1;...
Staphylococcus aureus infection -1.59 4.87e-2 72/95 (75.79%) C1R;KRT36;FPR3;...
Vitamin digestion and absorption -1.60 4.26e-2 17/24 (70.83%) ABCC1;MMACHC;PNLIP;...
Primary bile acid biosynthesis -1.61 3.99e-2 15/17 (88.24%) CYP39A1;SCP2;SLC27A5;...
Phenylalanine metabolism -1.63 3.74e-2 14/17 (82.35%) PAH;HPD;GOT1;...
Bile secretion -1.67 2.66e-2 68/90 (75.56%) ADCY6;SLC27A5;ABCC2;...
Mineral absorption -1.67 2.62e-2 48/60 (80%) CYBRD1;SLC8A2;ATP2B2;...
Glyoxylate and dicarboxylate metabolism -1.69 2.39e-2 23/30 (76.67%) CS;HAO1;GRHPR;...
Tyrosine metabolism -1.69 2.53e-2 30/36 (83.33%) FAH;ADH1C;HPD;...
Ubiquinone and other terpenoid-quinone biosynthesis -1.70 2.52e-2 9/11 (81.82%) VKORC1;HPD;NQO1;...
Steroid biosynthesis -1.74 1.98e-2 19/20 (95%) SQLE;NSDHL;LIPA;...
Alanine, aspartate and glutamate metabolism -1.78 1.37e-2 27/37 (72.97%) CPS1;ALDH5A1;ABAT;...
Cholesterol metabolism -1.80 1.10e-2 44/50 (88%) LIPA;ANGPTL8;NPC1;...
Synthesis and degradation of ketone bodies -1.80 1.19e-2 9/10 (90%) HMGCS1;ACAT1;HMGCS2
Fat digestion and absorption -1.81 8.58e-3 35/43 (81.4%) ABCG5;MTTP;ACAT1;...
PPAR signaling pathway -1.83 7.80e-3 66/74 (89.19%) ACSL3;CPT1A;FABP6;...
Folate biosynthesis -1.85 7.72e-3 23/26 (88.46%) GPHN;TPH1;SPR;...
Ribosome -1.91 4.77e-3 113/158 (71.52%) RPS15;RPL19;RPS27A;...
Arginine biosynthesis -1.95 0.00e+0 17/22 (77.27%) OTC;GLUD2;GLS;...
Drug metabolism -1.96 0.00e+0 78/151 (51.66%) CYP2C9;NME1;MPO;...
Retinol metabolism -2.01 0.00e+0 41/68 (60.29%) CYP2C9;RDH16;CYP2C8;...
Pentose and glucuronate interconversions -2.02 0.00e+0 17/34 (50%) CRYL1;DCXR;UGT2B4;...
Metabolism of xenobiotics by cytochrome P450 -2.08 0.00e+0 49/77 (63.64%) EPHX1;CYP2C9;CYP1B1;...
Glycine, serine and threonine metabolism -2.16 0.00e+0 31/40 (77.5%) DAO;SDS;PGAM1;...
Steroid hormone biosynthesis -2.17 0.00e+0 43/61 (70.49%) HSD17B12;CYP17A1;CYP1B1;...
Complement and coagulation cascades -2.56 0.00e+0 76/85 (89.41%) SERPINA5;KNG1;FGB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 8uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12.5uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H