Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGN4BY)

• Drug Name: Flurbiprofen Drug Info
• Synonyms: Adfeed; Adofeed; Anmetarin; Ansaid; Anside; Antadys; Cebutid; FLP; Flubiprofen; Flugalin; Flurbiprofene; Flurbiprofeno; Flurbiprofenum; Fluriproben; Flurofen; Froben; Ocufen; Ocuflur; Stayban; Yakuban; Zepolas; FLURBIPROFEN SODIUM; Froben Sr; BTS 18322; F0371; FP 70; IN1332; U 27182; Ansaid (TN); Apo-Flurbiprofen; BTS-18322; Flurbiprofene [INN-French]; Flurbiprofeno [INN-Spanish]; Flurbiprofenum [INN-Latin]; Froben (TN); MKS-11; Novo-Flurprofen; Nu-Flurbiprofen; U 27,182; U-27182; L-790,330; Flurbiprofen (JP15/USP/INN); Flurbiprofen [USAN:INN:BAN:JAN]; [+/-]-2-Fluoro-alpha-methyl-4-biphenylacetic acid; (+-)-2-(2-Fluoro-4-biphenylyl)propionic acid; (+-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid; (+/-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid; (+/-)-2-Fluoro-alpha-methyl[1,1′ -biphenyl]-4-acetic Acid; (1)-2-Fluoro-alpha-methyl(1,1'-biphenyl)-4-acetic acid; 2-(2-Fluorobiphenyl-4-yl)propionic Acid; 2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid; 2-(2-fluorobiphenyl-4-yl)propanoic acid; 2-(3-fluoro-4-phenylphenyl)propanoic acid; 2-Fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic acid; 2-Fluoro-alpha-methyl-4-biphenylacetic acid; 3-Fluoro-4-phenylhydratropic acid
• Therapeutic Class: Antiinflammatory Agents
• Cross-matching ID:
  PubChem CID: 3394
  ChEBI ID: CHEMBL563
  CAS Number: CAS 5104-49-4
  TTD Drug ID: D0A1PX
  VARIDT Drug ID: DR00587
  INTEDE Drug ID: DR0731
  ACDINA Drug ID: D00287

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.22	0.00e+0	34/36 (94.44%)	PCNA;FEN1;MCM5;...
Parkinson disease	2.09	0.00e+0	176/249 (70.68%)	GNAS;NDUFA6;CYCS;...
Oxidative phosphorylation	1.94	5.95e-3	93/133 (69.92%)	NDUFA6;ATP5PB;ATP5F1C;...
Diabetic cardiomyopathy	1.86	1.56e-2	162/203 (79.8%)	PLN;NDUFA6;COL1A2;...
Primary immunodeficiency	1.84	1.61e-2	33/38 (86.84%)	CD8A;IL7R;IL2RG;...
Prion disease	1.80	2.68e-2	209/273 (76.56%)	NDUFA6;PPP3CA;CYCS;...
Ribosome biogenesis in eukaryotes	1.77	3.57e-2	52/108 (48.15%)	NOP56;RPP38;RIOK2;...
Mismatch repair	1.75	3.68e-2	22/23 (95.65%)	PCNA;EXO1;RPA3;...
Fanconi anemia pathway	1.72	4.95e-2	36/54 (66.67%)	RAD51C;RMI1;BLM;...
Citrate cycle (TCA cycle)	1.69	4.68e-2	30/30 (100%)	IDH2;SDHD;SUCLA2;...
Nucleotide excision repair	1.68	4.53e-2	40/47 (85.11%)	PCNA;XPA;RPA3;...
MicroRNAs in cancer	-1.83	1.12e-2	146/310 (47.1%)	BMPR2;IRS1;SOS2;...
Nitrogen metabolism	-1.84	1.40e-2	16/17 (94.12%)	GLUD2;GLUD1;CA12;...
Proximal tubule bicarbonate reclamation	-1.85	1.86e-2	21/23 (91.3%)	PCK1;GLUD2;GLUD1;...
Pentose phosphate pathway	-1.86	2.79e-2	25/30 (83.33%)	TKT;RGN;TKTL1;...
Steroid hormone biosynthesis	-1.99	2.23e-2	43/61 (70.49%)	AKR1D1;UGT2B15;CYP17A1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H	Show ▼

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	12.5uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼