Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGO72P)

Drug Name
Oseltamivir Drug Info
Synonyms Tamiflu (*Phosphate salt 1:1*); Agucort; Oseltamivirum; Tamvir; GS 4104; GS4104; Agucort (TN); GS-4104; Oseltamivir (INN); Oseltamivir [INN:BAN]; Ro-640796; Tamiflu (TN); Tamiflu-Free; Ro-64-0796; OTV
Therapeutic ClassAntiviral Agents
Cross-matching ID
PubChem CID
65028
ChEBI ID
CHEMBL1229
CAS Number
CAS 196618-13-0
TTD Drug ID
D0O5NK
VARIDT Drug ID
DR00250
ACDINA Drug ID
D00494

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
NF-kappa B signaling pathway -1.64 4.81e-2 90/104 (86.54%) GADD45G;MYD88;PRKCB;...
Inflammatory bowel disease -1.64 4.76e-2 58/65 (89.23%) IFNGR2;STAT1;NOD2;...
Protein export -1.67 4.01e-2 17/23 (73.91%) SEC61B;SRP9;SRPRB;...
Pyrimidine metabolism -1.68 3.97e-2 40/56 (71.43%) UCK2;RRM2;ENTPD4;...
Neutrophil extracellular trap formation -1.70 3.13e-2 101/189 (53.44%) ITGA2B;C5;FPR1;...
Intestinal immune network for IgA production -1.73 2.25e-2 38/48 (79.17%) CD86;HLA-DRB1;AICDA;...
Sulfur relay system -1.73 2.44e-2 5/8 (62.5%) MPST;TST
Fatty acid degradation -1.83 8.18e-3 40/43 (93.02%) ACSL5;ADH1C;ECI2;...
Type I diabetes mellitus -1.84 6.75e-3 38/43 (88.37%) CD86;FAS;HLA-DRB1;...
Retinol metabolism -1.88 5.00e-3 41/68 (60.29%) CYP3A4;ALDH1A3;UGT2B15;...
Complement and coagulation cascades -1.90 2.81e-3 76/85 (89.41%) PLAT;PROC;C6;...
Graft-versus-host disease -1.93 3.21e-3 32/42 (76.19%) CD86;FAS;HLA-DRB1;...
Allograft rejection -1.93 3.75e-3 32/38 (84.21%) CD86;FAS;HLA-DRB1;...
Leishmaniasis -1.96 0.00e+0 67/77 (87.01%) NCF2;HLA-DRB1;MYD88;...
Asthma -2.00 0.00e+0 25/31 (80.65%) HLA-DRB1;PRG2;HLA-DOB;...
Mineral absorption -2.01 0.00e+0 48/60 (80%) SLC26A3;ATP1A2;MT1H;...
Ribosome -2.01 0.00e+0 113/158 (71.52%) RPS27A;RPL7;RPL6;...
Systemic lupus erythematosus -2.06 0.00e+0 45/135 (33.33%) C9;C5;CD86;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H