Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGO7QT)

Drug Name
INK128 Drug Info
Synonyms
1224844-38-5; Sapanisertib; INK-128; INK 128; INK 128 (MLN0128); TAK-228; UNII-JGH0DF1U03; JGH0DF1U03; 5-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]oxazol-2-amine; INK-0128; 3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; C15H15N7O; 5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine; 5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]-pyrimidin-3-yl)benzo[d]oxazol-2-amine; Sapanisertib (USAN/INN)
Cross-matching ID
PubChem CID
45375953
ChEBI ID
CHEMBL3545097
CAS Number
CAS 1224844-38-5
TTD Drug ID
D03DPZ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 1.93 1.94e-2 113/158 (71.52%) RPL36;RPL14;RPL26;...
ECM-receptor interaction 1.92 1.29e-2 80/88 (90.91%) ITGA3;ITGB5;ITGB4;...
Notch signaling pathway 1.85 1.94e-2 49/59 (83.05%) NCOR2;RFNG;DVL1;...
Oocyte meiosis -1.70 2.37e-2 90/129 (69.77%) REC8;CDK1;PPP2CB;...
Steroid hormone biosynthesis -1.70 2.36e-2 43/61 (70.49%) CYP1A1;CYP11A1;HSD11B2;...
Citrate cycle (TCA cycle) -1.70 2.40e-2 30/30 (100%) OGDH;PC;DLAT;...
Renal cell carcinoma -1.71 2.24e-2 68/69 (98.55%) PIK3R1;RAP1B;PIK3CB;...
Spinocerebellar ataxia -1.73 1.72e-2 128/143 (89.51%) PSMD8;KCND3;PIK3R1;...
Arginine and proline metabolism -1.74 1.47e-2 39/50 (78%) MAOA;GATM;OAT;...
HIF-1 signaling pathway -1.74 1.48e-2 105/109 (96.33%) ENO3;PIK3R1;LDHA;...
Synthesis and degradation of ketone bodies -1.74 1.55e-2 9/10 (90%) HMGCS1;ACAT2
Oxidative phosphorylation -1.74 1.62e-2 93/133 (69.92%) COX8A;NDUFB8;COX6B1;...
Fatty acid elongation -1.76 1.38e-2 19/27 (70.37%) HACD3;ACOT7;HSD17B12;...
Valine, leucine and isoleucine degradation -1.76 1.45e-2 42/48 (87.5%) OXCT1;BCAT1;PCCB;...
Fructose and mannose metabolism -1.77 1.45e-2 30/33 (90.91%) PFKFB3;TPI1;AKR1B10;...
Cysteine and methionine metabolism -1.79 1.32e-2 43/50 (86%) DNMT1;CTH;DNMT3B;...
Epstein-Barr virus infection -1.80 1.39e-2 189/202 (93.56%) B2M;MAPK9;IKBKG;...
DNA replication -1.80 1.40e-2 34/36 (94.44%) RPA2;RNASEH1;RNASEH2A;...
Pyruvate metabolism -1.85 7.02e-3 41/47 (87.23%) PC;ADH7;ALDH3A2;...
Huntington disease -1.87 3.76e-3 233/306 (76.14%) KIF5B;PIK3R4;MAPK9;...
Glycine, serine and threonine metabolism -1.88 4.05e-3 31/40 (77.5%) GNMT;MAOA;SRR;...
Amyotrophic lateral sclerosis -1.89 4.39e-3 267/364 (73.35%) NXT2;NUP37;NDUFA7;...
Butanoate metabolism -1.92 3.59e-3 23/28 (82.14%) ABAT;AACS;HMGCS1;...
Glycolysis / Gluconeogenesis -1.93 3.95e-3 56/67 (83.58%) GCK;BPGM;LDHC;...
Glutathione metabolism -1.94 4.39e-3 43/57 (75.44%) GSS;GSTM5;GSR;...
PPAR signaling pathway -1.95 4.94e-3 66/74 (89.19%) ACOX1;SCP2;APOA1;...
Prion disease -1.98 3.76e-3 209/273 (76.56%) KIF5B;MAPK9;COX8A;...
Parkinson disease -2.03 2.19e-3 176/249 (70.68%) KIF5B;MAPK9;COX8A;...
Protein processing in endoplasmic reticulum -2.04 2.63e-3 127/171 (74.27%) BAK1;DAD1;EDEM1;...
Biosynthesis of unsaturated fatty acids -2.09 0.00e+0 21/27 (77.78%) ACOX1;SCP2;HACD3;...
Terpenoid backbone biosynthesis -2.14 0.00e+0 18/22 (81.82%) MVK;MVD;PDSS1;...
Proteasome -2.25 0.00e+0 44/46 (95.65%) PSMD3;PSMD8;PSMB9;...
Steroid biosynthesis -2.45 0.00e+0 19/20 (95%) NSDHL;HSD17B7;FDFT1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Normal (Epithelial)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HME1 CVCL_2950 Homo sapiens 0.04uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUES 3 CVCL_B062 Homo sapiens 0.04uM - 3.33uM 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
A549/Asc-1 CVCL_YA87 Homo sapiens 0.04uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
SK-L CVCL_1699 Homo sapiens 0.04uM - 10uM 24H