Details of the Drug Pharmacogenomic Perturbation Atlas

Otamixaban Drug Info

Methyl 2-[(3-carbamimidoylphenyl)methyl]-3-[[4-(1-oxidopyridin-4-yl)benzoyl]amino]butanoate; Methyl (2R,3R)-2-[(3-carbamimidoylphenyl)methyl]-3-[[4-(1-oxidopyridin-1-ium-4-yl)benzoyl]amino]butanoate; 2-(3-Carbamimidoylbenzyl)-3-(4-(1-oxypyridin-4-yl)benzoylamino)butyric acid methyl ester

Cross-matching ID

PubChem CID

5496659

ChEBI ID

CHEMBL46618

CAS Number

CAS 193153-04-7

TTD Drug ID

D0E2MJ

General Information of Drug (ID: DMGOPMK)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Oxidative phosphorylation	2.08	0.00e+0	93/133 (69.92%)	COX7B;COX6B1;NDUFB1;...
Steroid biosynthesis	1.89	1.44e-2	19/20 (95%)	MSMO1;CYP24A1;CYP51A1;...
TGF-beta signaling pathway	1.84	2.64e-2	81/94 (86.17%)	ID3;TGFBR2;ID4;...
Mismatch repair	1.80	3.24e-2	22/23 (95.65%)	RFC5;RFC3;MLH1;...
Arginine and proline metabolism	1.72	4.90e-2	39/50 (78%)	SAT1;ALDH2;AOC1;...
Nucleotide excision repair	1.72	4.44e-2	40/47 (85.11%)	POLE3;CETN2;RAD23B;...
Calcium signaling pathway	-1.69	4.95e-2	213/240 (88.75%)	SLC25A6;P2RX1;TNNC1;...
Bile secretion	-1.69	4.84e-2	68/90 (75.56%)	SLC4A2;ATP1A1;SCARB1;...
Ether lipid metabolism	-1.78	2.10e-2	32/49 (65.31%)	PLA2G4A;PLPP1;GDPD3;...
Aldosterone synthesis and secretion	-1.81	1.65e-2	85/98 (86.73%)	ADCY6;CAMK2B;HSD3B1;...
Inositol phosphate metabolism	-1.83	1.39e-2	66/73 (90.41%)	MTM1;PTEN;PIP5K1B;...
Nicotine addiction	-1.89	8.83e-3	32/40 (80%)	GRIN2A;SLC17A6;SLC17A7;...
Insulin secretion	-1.92	6.18e-3	75/86 (87.21%)	ADCY6;CAMK2B;CHRM3;...
Cortisol synthesis and secretion	-1.92	7.42e-3	58/65 (89.23%)	HSD3B1;CREB3L1;SCARB1;...
Estrogen signaling pathway	-1.93	9.28e-3	119/137 (86.86%)	KRT17;HSP90AA1;CTSD;...
Regulation of lipolysis in adipocytes	-1.94	1.24e-2	52/55 (94.55%)	PTGS2;ADCY6;PLIN1;...
Steroid hormone biosynthesis	-2.03	0.00e+0	43/61 (70.49%)	SRD5A1;AKR1C3;HSD3B1;...
Ovarian steroidogenesis	-2.30	0.00e+0	41/51 (80.39%)	PTGS2;ADCY6;PLA2G4A;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.01uM - 10uM	24H

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.04uM - 10uM	24H

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 10uM	24H