General Information of Drug (ID: DMGOURX)

Drug Name
USNIC ACID Drug Info
Synonyms
usnic acid; 125-46-2; Usniacin; Usno; Usninsaeure [German]; (+-)-Uanic acid; usnic-acid; Usinic acid; L-Usnic acid; NSC 8517; CCRIS 5518; HSDB 7170; NSC5890; 1,3(2H,9bH)-Dibenzofurandione, 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl-; C18H16O7; EINECS 204-740-7; BRN 1299865; 2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyl-1,3(2H,9bH)-dibenzofurandione; AI3-50457; CHEBI:2264; NSC8517; NSC5889; 2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzo[b,d]furan-1,3(2H,9bh)-dione
Cross-matching ID
PubChem CID
5646
ChEBI ID
CHEMBL2264
CAS Number
CAS 125-46-2
TTD Drug ID
D09JSD

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Asthma 1.75 2.90e-1 25/31 (80.65%) PRG2;HLA-DPA1;EPX;...
Arachidonic acid metabolism 1.55 7.99e-1 48/61 (78.69%) ALOX5;GPX3;GPX1;...
Thyroid hormone synthesis 1.50 8.20e-1 66/75 (88%) GPX3;TG;GPX1;...
Glutathione metabolism 1.47 7.30e-1 43/57 (75.44%) GPX3;GPX1;GGT1;...
Base excision repair 1.44 7.36e-1 29/33 (87.88%) POLE3;HMGB1;NEIL3;...
Fc epsilon RI signaling pathway 1.43 6.62e-1 57/68 (83.82%) ALOX5;ALOX5AP;MAPK13;...
Mannose type O-glycan biosynthesis 1.38 8.64e-1 14/23 (60.87%) RXYLT1;CHST10;POMT1;...
Histidine metabolism 1.37 8.22e-1 16/22 (72.73%) MAOA;AOC1;ALDH1B1;...
Oxytocin signaling pathway 1.26 8.88e-1 128/154 (83.12%) GNAI1;CAMK1;ADCY9;...
Renin secretion 1.22 8.82e-1 61/69 (88.41%) AGT;GNAI1;GNAQ;...
Aminoacyl-tRNA biosynthesis 1.19 8.83e-1 15/66 (22.73%) NARS2;GATB;LARS2;...
Retrograde endocannabinoid signaling 1.19 8.71e-1 118/148 (79.73%) GNAI1;NDUFS7;GNB1;...
GnRH signaling pathway 1.18 8.87e-1 80/93 (86.02%) GNA11;ADCY9;MAPK13;...
Protein export 1.18 8.61e-1 17/23 (73.91%) SPCS3;HSPA5;SRPRA;...
Dopaminergic synapse 1.18 8.50e-1 115/132 (87.12%) MAOA;GNAI1;GNB1;...
Glycerophospholipid metabolism 1.17 8.45e-1 71/98 (72.45%) CDS1;GPD1L;PLPP3;...
Hippo signaling pathway 1.16 8.52e-1 120/186 (64.52%) BMP2;SMAD1;CCND2;...
Ubiquinone and other terpenoid-quinone biosynthesis 1.15 8.77e-1 9/11 (81.82%) COQ2;COQ7;HPD;...
Aldosterone synthesis and secretion 1.15 8.77e-1 85/98 (86.73%) KCNK3;AGT;GNA11;...
Vasopressin-regulated water reabsorption 1.14 8.64e-1 40/44 (90.91%) ARHGDIB;ADCY9;DYNC1I2;...
Fanconi anemia pathway 1.14 8.48e-1 36/54 (66.67%) FANCC;PALB2;USP1;...
Biosynthesis of unsaturated fatty acids 1.14 8.36e-1 21/27 (77.78%) ELOVL5;HACD3;ACOX1;...
Cortisol synthesis and secretion 1.14 8.23e-1 58/65 (89.23%) KCNK3;AGT;GNA11;...
Morphine addiction 1.13 8.24e-1 80/91 (87.91%) PDE4B;GNAI1;GNB1;...
DNA replication 1.13 8.09e-1 34/36 (94.44%) RFC5;POLE3;MCM6;...
Phenylalanine metabolism 1.13 7.89e-1 14/17 (82.35%) MAOA
Regulation of lipolysis in adipocytes 1.12 8.16e-1 52/55 (94.55%) NPY;GNAI1;ADCY9;...
Cell adhesion molecules 1.11 8.33e-1 118/148 (79.73%) ICAM2;ALCAM;CLDN4;...
Platelet activation 1.10 8.68e-1 106/124 (85.48%) GNAI1;ADCY9;MAPK13;...
Thiamine metabolism 1.08 9.01e-1 12/15 (80%) AK1;AK2
Mitophagy -1.32 3.95e-1 56/68 (82.35%) MFN1;RRAS2;TBK1;...
AMPK signaling pathway -1.32 4.03e-1 106/120 (88.33%) PPP2CB;PPP2R1A;PRKAB2;...
Retinol metabolism -1.32 4.00e-1 41/68 (60.29%) CYP3A7;CYP3A4;ALDH1A2;...
Hematopoietic cell lineage -1.33 3.83e-1 90/99 (90.91%) ITGA1;ITGAM;CD1E;...
Sulfur relay system -1.33 3.89e-1 5/8 (62.5%) NFS1;MOCS2
Sulfur metabolism -1.34 3.85e-1 9/10 (90%) SQOR;BPNT1;PAPSS2;...
Thyroid hormone signaling pathway -1.34 3.91e-1 112/121 (92.56%) NOTCH2;PIK3R2;ATP1B4;...
TNF signaling pathway -1.35 3.85e-1 103/112 (91.96%) EDN1;TNFRSF1A;AKT3;...
Porphyrin and chlorophyll metabolism -1.36 3.83e-1 23/43 (53.49%) UGT2B4;UGT2B15;HMOX1;...
ECM-receptor interaction -1.36 3.91e-1 80/88 (90.91%) TNXB;THBS4;DAG1;...
Salmonella infection -1.36 4.02e-1 198/249 (79.52%) RAB5A;TRADD;DYNC2LI1;...
Autophagy -1.41 3.74e-1 113/169 (66.86%) PIK3R2;ATG101;INS;...
Complement and coagulation cascades -1.42 3.64e-1 76/85 (89.41%) FGA;FGG;F8;...
Antigen processing and presentation -1.42 3.79e-1 60/78 (76.92%) RFXAP;NFYC;HLA-DQA1;...
Ferroptosis -1.42 3.91e-1 36/41 (87.8%) PCBP1;ATG5;PRNP;...
Prostate cancer -1.48 2.99e-1 93/97 (95.88%) CREB3L2;PLAU;HSP90B1;...
Legionellosis -1.49 2.86e-1 51/57 (89.47%) TLR5;RAB1A;IL12B;...
Shigellosis -1.52 2.41e-1 180/246 (73.17%) BCL10;TBK1;RRAGB;...
IL-17 signaling pathway -1.52 2.49e-1 84/94 (89.36%) CXCL6;FADD;IFNG;...
Central carbon metabolism in cancer -1.52 2.69e-1 67/70 (95.71%) PFKM;SLC2A1;PIK3CD;...
Leukocyte transendothelial migration -1.52 2.90e-1 90/114 (78.95%) MYL12B;ACTN1;EZR;...
Bladder cancer -1.55 2.67e-1 40/41 (97.56%) DAPK1;RPS6KA5;MMP9;...
HIF-1 signaling pathway -1.55 2.82e-1 105/109 (96.33%) EDN1;LDHB;HIF1A;...
Malaria -1.56 3.06e-1 44/50 (88%) SDC2;IL12A;THBS4;...
Inositol phosphate metabolism -1.57 3.07e-1 66/73 (90.41%) PI4KB;INPP5F;PIP4K2C;...
Rheumatoid arthritis -1.61 2.77e-1 78/93 (83.87%) ITGAL;ATP6V1A;ACP5;...
Protein digestion and absorption -1.62 3.01e-1 78/103 (75.73%) ATP1B2;CELA2A;SLC8A1;...
Glycolysis / Gluconeogenesis -1.62 3.68e-1 56/67 (83.58%) ADH7;PGK1;ENO3;...
Mineral absorption -1.67 2.83e-1 48/60 (80%) ATP1B2;SLC26A6;SLC8A1;...
Viral protein interaction with cytokine and cytokine re... -1.70 3.11e-1 84/100 (84%) CCR1;CXCL6;IL2RB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H