Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGQFYB)

• Drug Name: Mecamylamine Drug Info
• Synonyms: Mecamilamina; Mecamine; Mecamylaminum; Mekamine; Mevasine; Revertina; Versamine; Inversine hydrochloride; Mecamilamina [DCIT]; Mecamilamina [Italian]; Mevasin hydrochloride; Inversine (TN); Mecamylamine [INN:BAN]; Mecamylaminum [INN-Latin]; N-Methyl-2-isocamphanamine; N,2,3,3-Tetramethyl-2-norbornamine; N,2,3,3-Tetramethyl-2-norcamphanamine; N,2,2,3-tetramethylbicyclo[2.2.1]heptan-3-amine; N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine; 2-Methylamino-2,3,3-trimethylnorbornane; 2-Methylaminoisocamphane; 3-Methylaminoisocamphane; 3-Methylaminoisokamfan; 3-Methylaminoisokamfan [Czech]; 3-beta-Methylamino-2,2,3-trimethylbicyclo(2.2.1)heptane
• Therapeutic Class: Antihypertensive Agents
• Cross-matching ID:
  PubChem CID: 4032
  ChEBI ID: CHEMBL267936
  CAS Number: CAS 60-40-2
  TTD Drug ID: D0V8HA
  ACDINA Drug ID: D00386

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.40	0.00e+0	34/36 (94.44%)	PCNA;MCM5;MCM6;...
Mismatch repair	2.23	0.00e+0	22/23 (95.65%)	PCNA;MSH6;MLH1;...
Cell cycle	1.92	1.17e-2	110/124 (88.71%)	PCNA;CDC25B;ESPL1;...
Progesterone-mediated oocyte maturation	1.81	2.34e-2	75/100 (75%)	STK10;CDC25B;ADCY9;...
Glycolysis / Gluconeogenesis	1.80	2.10e-2	56/67 (83.58%)	GAPDH;PGAM1;DLD;...
Galactose metabolism	1.79	2.34e-2	26/31 (83.87%)	AKR1B1;AKR1B10;GLA;...
Ether lipid metabolism	1.77	3.50e-2	32/49 (65.31%)	LPCAT1;PLA2G4A;PLAAT3;...
Spliceosome	1.74	4.52e-2	101/150 (67.33%)	HSPA8;PRPF8;SF3B3;...
Ribosome biogenesis in eukaryotes	1.72	4.54e-2	52/108 (48.15%)	EIF6;NOP56;DKC1;...
Base excision repair	1.71	4.20e-2	29/33 (87.88%)	PCNA;FEN1;POLD2;...
Fanconi anemia pathway	1.69	4.78e-2	36/54 (66.67%)	MLH1;FANCI;BRCA1;...
Terpenoid backbone biosynthesis	-1.83	4.88e-2	18/22 (81.82%)	DHDDS;PMVK;PDSS1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼