Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGQU0Y)

Drug Name
Piperacetazine Drug Info
Synonyms Quide
Cross-matching ID
PubChem CID
19675
ChEBI ID
CHEMBL1584
CAS Number
CAS 3819-00-9
TTD Drug ID
D0AO6B

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
RNA degradation 1.99 0.00e+0 53/79 (67.09%) TOB1;CNOT4;BTG2;...
Fatty acid biosynthesis 1.95 0.00e+0 16/18 (88.89%) FASN;ACSL4;ACSL6;...
DNA replication 1.95 2.36e-3 34/36 (94.44%) RPA3;RNASEH2A;RPA2;...
Cell cycle 1.80 2.30e-2 110/124 (88.71%) CDC20;CHEK1;SKP2;...
ECM-receptor interaction -1.74 4.59e-2 80/88 (90.91%) TNN;GP1BA;ITGB3;...
Antigen processing and presentation -1.80 2.91e-2 60/78 (76.92%) HSPA8;KLRD1;HSP90AB1;...
Asthma -1.80 3.23e-2 25/31 (80.65%) HLA-DMB;HLA-DRA;HLA-DQA1;...
Endocrine and other factor-regulated calcium reabsorpti... -1.80 3.47e-2 49/53 (92.45%) ADCY6;PRKCA;KLK1;...
Adrenergic signaling in cardiomyocytes -1.81 3.07e-2 130/150 (86.67%) SCN5A;SLC9A1;MYH7;...
Gastric acid secretion -1.83 2.32e-2 63/76 (82.89%) ATP4A;HRH2;SLC9A1;...
Thyroid hormone synthesis -1.98 5.05e-3 66/75 (88%) ADCY6;PRKCA;CREB3L2;...
Dilated cardiomyopathy -1.99 3.16e-3 86/96 (89.58%) ITGB3;MYH7;ITGA3;...
Citrate cycle (TCA cycle) -1.99 4.21e-3 30/30 (100%) PCK1;MDH1;SDHD;...
Intestinal immune network for IgA production -2.00 6.32e-3 38/48 (79.17%) HLA-DMB;HLA-DRA;CD86;...
Protein digestion and absorption -2.26 0.00e+0 78/103 (75.73%) MEP1B;CELA3B;SLC15A1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H