Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGRBN5)

Drug Name
TESAGLITAZAR Drug Info
Synonyms
Tesaglitazar; 251565-85-2; Galida; (S)-2-Ethoxy-3-(4-(4-((methylsulfonyl)oxy)phenethoxy)phenyl)propanoic acid; AZ 242; AZ-242; AR-H039242XX; (S)-2-Ethoxy-3-{4-[2-(4-methanesulfonyloxyphenyl)ethoxy]phenyl}propionic acid; UNII-6734037O3L; (S)-2-Ethoxy-3-{4-[2-(4-methanesulfonyloxy-phenyl)-ethoxy]-phenyl}-propionic acid; (2S)-2-ethoxy-3-[4-[2-(4-methylsulfonyloxyphenyl)ethoxy]phenyl]propanoic acid; BR-44608; 6734037O3L; (S)-2-Ethoxy-3-[4-[2-(4-methanesulfonyloxyphenyl)ethoxy]phenyl]propanoic acid
Cross-matching ID
PubChem CID
208901
ChEBI ID
CHEMBL282686
CAS Number
CAS 251565-85-2
TTD Drug ID
D0H1NL

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.31 0.00e+0 34/36 (94.44%) FEN1;MCM6;POLE3;...
Legionellosis 2.21 0.00e+0 51/57 (89.47%) CASP7;CD14;IL1B;...
Leishmaniasis 2.09 3.90e-3 67/77 (87.01%) PRKCB;NCF2;FCGR3B;...
Spliceosome 1.94 8.77e-3 101/150 (67.33%) LSM5;PRPF4;HSPA1A;...
Ribosome biogenesis in eukaryotes 1.94 1.17e-2 52/108 (48.15%) XPO1;NOP56;DKC1;...
Porphyrin and chlorophyll metabolism 1.90 9.74e-3 23/43 (53.49%) HMBS;UGT2B17;UGT2B15;...
Cell cycle 1.87 1.34e-2 110/124 (88.71%) CDC20;CCND2;CDC25A;...
Pyrimidine metabolism 1.77 3.65e-2 40/56 (71.43%) CTPS1;ENTPD1;UPP1;...
Glycolysis / Gluconeogenesis -1.88 2.46e-2 56/67 (83.58%) ALDH2;FBP1;DLD;...
Cardiac muscle contraction -2.01 8.21e-3 64/87 (73.56%) MYL3;COX5A;TPM1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone marrow
Neuroblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SH-SY5Y CVCL_0019 Homo sapiens 0.04uM - 10uM 24H
SK-N-SH CVCL_0531 Homo sapiens 0.04uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.04uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H