Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGT0KV)

Drug Name
Maxacalcitol Drug Info
Synonyms Prezios (TN)
Cross-matching ID
PubChem CID
6398761
ChEBI ID
CHEMBL333950
CAS Number
CAS 103909-75-7
TTD Drug ID
D05BTM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
ECM-receptor interaction 2.26 0.00e+0 80/88 (90.91%) SDC4;THBS1;COL4A1;...
Focal adhesion 2.15 0.00e+0 180/201 (89.55%) THBS1;PDGFA;COL4A1;...
Protein digestion and absorption 2.08 0.00e+0 78/103 (75.73%) COL4A1;COL1A1;COL1A2;...
Fluid shear stress and atherosclerosis 2.04 0.00e+0 123/139 (88.49%) SDC4;PLAT;MAPK13;...
Amoebiasis 2.01 2.55e-3 99/102 (97.06%) CXCL2;COL4A1;IL1B;...
Rheumatoid arthritis 2.01 2.12e-3 78/93 (83.87%) CXCL2;IL1B;IL1A;...
Epithelial cell signaling in Helicobacter pylori infect... 2.01 1.82e-3 62/70 (88.57%) CXCL2;MAPK13;CXCL1;...
PI3K-Akt signaling pathway 1.97 3.18e-3 317/354 (89.55%) THBS1;PDGFA;LPAR1;...
Regulation of actin cytoskeleton 1.91 5.66e-3 185/218 (84.86%) PDGFA;LPAR1;FN1;...
Bacterial invasion of epithelial cells 1.89 7.64e-3 59/77 (76.62%) FN1;MET;CAV2;...
Bladder cancer 1.89 6.94e-3 40/41 (97.56%) THBS1;E2F2;CDKN1A;...
Glutathione metabolism 1.86 9.55e-3 43/57 (75.44%) GPX3;GSTP1;GPX1;...
Axon guidance 1.86 9.79e-3 151/182 (82.97%) DPYSL2;WNT5A;RHOD;...
TNF signaling pathway 1.86 9.09e-3 103/112 (91.96%) CXCL2;MAPK13;IL1B;...
Small cell lung cancer 1.84 9.34e-3 90/92 (97.83%) COL4A1;CCNE2;LAMB1;...
p53 signaling pathway 1.83 8.75e-3 63/73 (86.3%) THBS1;IGFBP3;CCNE2;...
Gap junction 1.83 8.24e-3 72/88 (81.82%) PDGFA;LPAR1;GJA1;...
AGE-RAGE signaling pathway in diabetic complications 1.83 7.78e-3 97/100 (97%) MAPK13;F3;COL4A1;...
Pathogenic Escherichia coli infection 1.82 8.04e-3 152/197 (77.16%) MAPK13;LPAR1;IL1B;...
Proteoglycans in cancer 1.78 1.02e-2 172/205 (83.9%) SDC4;THBS1;MAPK13;...
Sulfur metabolism 1.78 9.70e-3 9/10 (90%) PAPSS2;SQOR;TST;...
Melanoma 1.78 9.84e-3 68/72 (94.44%) PDGFA;PDGFRA;MET;...
Relaxin signaling pathway 1.78 9.41e-3 114/129 (88.37%) MAPK13;COL4A1;COL1A1;...
Pyrimidine metabolism 1.74 1.70e-2 40/56 (71.43%) UPP1;NT5E;RRM1;...
IL-17 signaling pathway 1.72 2.09e-2 84/94 (89.36%) CXCL2;MAPK13;IL1B;...
Folate biosynthesis 1.72 2.06e-2 23/26 (88.46%) AKR1B1;AKR1C3;QDPR;...
Glycerolipid metabolism 1.70 2.59e-2 44/61 (72.13%) AKR1B1;MGLL;PLPP3;...
Steroid biosynthesis 1.70 2.59e-2 19/20 (95%) NSDHL;MSMO1;LSS;...
Rap1 signaling pathway 1.69 2.77e-2 184/210 (87.62%) THBS1;MAPK13;PDGFA;...
Fructose and mannose metabolism 1.68 2.67e-2 30/33 (90.91%) FBP1;AKR1B1;PFKFB3;...
RNA transport -1.73 3.57e-2 128/186 (68.82%) NUP160;CLNS1A;TARDBP;...
Ribosome -1.83 1.65e-2 113/158 (71.52%) RPL28;RPS19;RPL7A;...
Ribosome biogenesis in eukaryotes -2.01 0.00e+0 52/108 (48.15%) GNL3L;PWP2;NXF2;...
Spliceosome -2.53 0.00e+0 101/150 (67.33%) SF3A1;PPIE;PRPF31;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colon carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 TP53(-/-) CVCL_HD97 Homo sapiens 0.02uM - 4uM 24H
HCT 116 CVCL_0291 Homo sapiens 0.02uM - 4uM 24H
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 (Parent) CVCL_0291 Homo sapiens 0.02uM - 4uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H