General Information of Drug (ID: DMGTAWC)

Drug Name
RKI-1447 Drug Info
Synonyms RKI1447; compound 5g [PMID 23275831]
Cross-matching ID
PubChem CID
60138149
ChEBI ID
CHEMBL3218011
TTD Drug ID
D03CPB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Mineral absorption 2.29 0.00e+0 48/60 (80%) MT1E;MT1H;MT1G;...
Systemic lupus erythematosus 2.15 0.00e+0 45/135 (33.33%) CD40;CTSG;ELANE;...
Staphylococcus aureus infection 1.96 3.00e-3 72/95 (75.79%) DEFB1;CFB;KRT17;...
Ribosome biogenesis in eukaryotes 1.88 6.74e-3 52/108 (48.15%) MDN1;GNL3;EIF6;...
Valine, leucine and isoleucine degradation 1.87 1.08e-2 42/48 (87.5%) ABAT;ACAT1;AOX1;...
Fatty acid degradation 1.87 8.99e-3 40/43 (93.02%) ACAT1;ACADVL;ECI2;...
Viral protein interaction with cytokine and cytokine re... 1.87 7.70e-3 84/100 (84%) CXCL12;CXCL14;CXCL6;...
Intestinal immune network for IgA production 1.85 8.99e-3 38/48 (79.17%) CXCL12;CD40;IL15RA;...
Porphyrin and chlorophyll metabolism 1.84 8.99e-3 23/43 (53.49%) CPOX;UGT2B28;UGT2A3;...
Cytokine-cytokine receptor interaction 1.82 1.26e-2 246/295 (83.39%) CXCL12;CD40;CXCL14;...
Proximal tubule bicarbonate reclamation 1.72 3.43e-2 21/23 (91.3%) CA2;SLC4A4;GLS;...
D-Glutamine and D-glutamate metabolism 1.71 3.67e-2 5/5 (100%) GLS;GLUD1;DGLUCY;...
Purine metabolism 1.69 4.15e-2 102/129 (79.07%) AK4;ADCY9;AMPD2;...
beta-Alanine metabolism 1.67 4.67e-2 25/30 (83.33%) ABAT;HIBCH;ACOX3;...
Vascular smooth muscle contraction -1.92 2.25e-2 113/133 (84.96%) PLCB1;EDNRA;PPP1R12B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H