Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGTW1I)

Drug Name
Pirarubicin Drug Info
Synonyms Pinorubicin (TN); Therarubucin (TN)
Cross-matching ID
PubChem CID
636397
ChEBI ID
CHEMBL32011
CAS Number
CAS 72496-41-4
TTD Drug ID
D0T8EH
VARIDT Drug ID
DR01430

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Type I diabetes mellitus 2.47 0.00e+0 38/43 (88.37%) HLA-DQA1;HLA-B;HLA-C;...
Graft-versus-host disease 2.36 0.00e+0 32/42 (76.19%) HLA-DQA1;HLA-B;HLA-C;...
Autoimmune thyroid disease 2.32 0.00e+0 46/53 (86.79%) HLA-DQA1;HLA-B;HLA-C;...
Allograft rejection 2.32 0.00e+0 32/38 (84.21%) HLA-DQA1;HLA-B;HLA-C;...
Antigen processing and presentation 2.27 0.00e+0 60/78 (76.92%) HLA-DQA1;TAP1;HLA-B;...
Lysosome 2.16 0.00e+0 115/128 (89.84%) CTSV;LITAF;CTSL;...
Rheumatoid arthritis 2.06 0.00e+0 78/93 (83.87%) HLA-DQA1;CTSL;CCL5;...
p53 signaling pathway 2.01 0.00e+0 63/73 (86.3%) CCND2;IGF1;RRM2;...
Inflammatory bowel disease 1.94 1.12e-3 58/65 (89.23%) HLA-DQA1;MAF;HLA-DRB1;...
Phagosome 1.93 1.01e-3 118/152 (77.63%) HLA-DQA1;TAP1;HLA-B;...
Epstein-Barr virus infection 1.92 9.17e-4 189/202 (93.56%) HLA-DQA1;TAP1;HLA-B;...
Other glycan degradation 1.92 8.40e-4 13/18 (72.22%) FUCA1;NEU1;HEXB;...
Viral myocarditis 1.91 7.76e-4 53/60 (88.33%) HLA-DQA1;HLA-B;HLA-C;...
Oxidative phosphorylation 1.91 7.20e-4 93/133 (69.92%) ATP5F1E;ATP6AP1;NDUFA4;...
Fatty acid elongation 1.79 8.74e-3 19/27 (70.37%) HACD1;HADHB;HACD2;...
Viral protein interaction with cytokine and cytokine re... 1.78 8.82e-3 84/100 (84%) CCL4;CCL5;CXCL11;...
Malaria 1.73 2.25e-2 44/50 (88%) SDC2;HBB;COMP;...
Glycosaminoglycan degradation 1.73 2.13e-2 19/19 (100%) GALNS;HPSE;HEXB;...
Th1 and Th2 cell differentiation 1.72 2.23e-2 80/92 (86.96%) HLA-DQA1;NFATC3;MAF;...
Asthma 1.70 2.52e-2 25/31 (80.65%) HLA-DQA1;HLA-DRB1;IL5;...
Herpes simplex virus 1 infection 1.70 2.40e-2 165/498 (33.13%) HLA-DQA1;TAP1;HLA-B;...
Cell adhesion molecules 1.68 2.75e-2 118/148 (79.73%) HLA-DQA1;HLA-B;HLA-C;...
Citrate cycle (TCA cycle) 1.67 2.94e-2 30/30 (100%) ACLY;MDH1;SUCLG2;...
Influenza A 1.61 4.62e-2 156/172 (90.7%) HLA-DQA1;TMPRSS2;CCL5;...
Cytokine-cytokine receptor interaction 1.60 4.65e-2 246/295 (83.39%) CCL4;CCL5;CXCL11;...
Purine metabolism 1.59 4.63e-2 102/129 (79.07%) PNP;PDE10A;PRPS2;...
Hematopoietic cell lineage 1.59 4.50e-2 90/99 (90.91%) CD9;HLA-DQA1;GP1BB;...
Glutathione metabolism 1.59 4.66e-2 43/57 (75.44%) ODC1;GSTM3;GSTT1;...
Sphingolipid metabolism 1.58 4.64e-2 32/49 (65.31%) DEGS1;PLPP1;NEU1;...
Non-alcoholic fatty liver disease 1.57 4.74e-2 126/155 (81.29%) CYCS;NDUFA4;NDUFA6;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H