Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DMGV8QU)

Drug Name
Etravirine Drug Info
Synonyms
Intelence; DAPY deriv; Diaminopyrimidine deriv; R 165335; R165335; TMC 125; TMC125; Intelence (TN); Intelence(TM); R-165335; R165335-TMC125; TMC-125; Etravirine (JAN/USAN/INN); TMC-125/R-165335; 4-((6-amino-5-bromo-2-((4-cyanophenyl)amino)-4-pyrimidinyl)oxy)-3,5-dimethyl-benzonitrile; 4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE; 4-[6-amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yl]oxy-3,5-dimethylbenzonitrile; 65B; ETR
Cross-matching ID
PubChem CID
193962
ChEBI ID
CHEMBL308954
CAS Number
CAS 269055-15-4
TTD Drug ID
D0BP9C
VARIDT Drug ID
DR00597
INTEDE Drug ID
DR0671
ACDINA Drug ID
D00259

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mineral absorption 2.18 0.00e+0 48/60 (80%) MT1F;MT1X;STEAP1;...
Ferroptosis 2.14 0.00e+0 36/41 (87.8%) SLC7A11;SAT1;SLC39A8;...
IL-17 signaling pathway 2.00 0.00e+0 84/94 (89.36%) CXCL8;CXCL2;CXCL5;...
Primary bile acid biosynthesis 1.96 0.00e+0 15/17 (88.24%) AMACR;ACOX2;CYP39A1;...
Chemokine signaling pathway 1.84 1.05e-2 163/192 (84.9%) CXCL8;CXCL2;CXCL5;...
Kaposi sarcoma-associated herpesvirus infection 1.81 2.19e-2 172/193 (89.12%) CXCL8;CXCL2;CXCL3;...
Bladder cancer 1.78 3.00e-2 40/41 (97.56%) CXCL8;E2F2;MMP1;...
NOD-like receptor signaling pathway 1.76 3.28e-2 145/181 (80.11%) CXCL8;CXCL2;CXCL3;...
Glutathione metabolism 1.73 4.52e-2 43/57 (75.44%) GPX2;GSTM3;IDH1;...
Ovarian steroidogenesis -1.66 4.40e-2 41/51 (80.39%) HSD3B1;ADCY8;HSD17B7;...
Hematopoietic cell lineage -1.67 4.30e-2 90/99 (90.91%) ITGA1;HLA-DPA1;CSF2RA;...
Fanconi anemia pathway -1.69 3.93e-2 36/54 (66.67%) REV1;POLH;TELO2;...
Regulation of lipolysis in adipocytes -1.71 4.02e-2 52/55 (94.55%) NPR1;ADRB2;INS;...
Systemic lupus erythematosus -1.76 3.10e-2 45/135 (33.33%) C7;HLA-DRB1;C6;...
DNA replication -1.86 1.43e-2 34/36 (94.44%) MCM7;MCM3;POLA2;...
Spliceosome -1.86 1.91e-2 101/150 (67.33%) PRPF38B;SNRNP200;DHX16;...
Asthma -1.92 1.15e-2 25/31 (80.65%) HLA-DRB1;PRG2;HLA-DPA1;...
Ribosome biogenesis in eukaryotes -2.05 5.74e-3 52/108 (48.15%) NHP2;POP1;RPP38;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.04uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H